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PHF13 Activates Enhancers to Promote TGFβ-Induced Epithelial-to-Mesenchymal Transition [RNA-Seq]

ABSTRACT: PHF13 Activates Enhancers to Promote TGFβ-Induced Epithelial-to-Mesenchymal Transition [RNA-Seq]

PROVIDER: PRJNA692164 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR13435887_1.fastq.gz	Fastqsanger.gz
	SRR13435887_2.fastq.gz	Fastqsanger.gz
	SRR13435888_1.fastq.gz	Fastqsanger.gz
	SRR13435888_2.fastq.gz	Fastqsanger.gz
	SRR13435889_1.fastq.gz	Fastqsanger.gz

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PHF13 Activates Enhancers to Promote TGFβ-Induced Epithelial-to-Mesenchymal Transition [RNA-Seq]

Project description:We investigated the role of PHF13 in TGFβ-induced Epithelial-to-Mesenchymal Transition and found PHF13 is essential for TGFβ-promoted broadest H3K4me3 domains and super-enhancers activation.

2022-05-25 | GSE164821 | GEO

PHF13 Activates Enhancers to Promote TGFb-Induced Epithelial-to-Mesenchymal Transition [ChIP-Seq]

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PHF13 Activates Enhancers to Promote TGFb-Induced Epithelial-to-Mesenchymal Transition

Project description:PHF13 Activates Enhancers to Promote TGFb-Induced Epithelial-to-Mesenchymal Transition

| PRJNA692160 | ENA

PHF13 Activates Enhancers to Promote TGFb-Induced Epithelial-to-Mesenchymal Transition [ChIP-Seq]

Project description:PHF13 Activates Enhancers to Promote TGFb-Induced Epithelial-to-Mesenchymal Transition [ChIP-Seq]

| PRJNA692161 | ENA

PHF13 epigenetically activates TGFβ driven epithelial to mesenchymal transition.

Project description:Epigenetic alteration is a pivotal factor in tumor metastasis. PHD finger protein 13 (PHF13) is a recently identified epigenetic reader of H3K4me2/3 that functions as a transcriptional co-regulator. In this study, we demonstrate that PHF13 is required for pancreatic-cancer-cell growth and metastasis. Integrative analysis of transcriptome and epigenetic profiles provide further mechanistic insights into the epigenetic regulation of genes associated with cell metastasis during the epithelial-to-mesenchymal transition (EMT) induced by transforming growth factor β (TGFβ). Our data suggest PHF13 depletion impairs activation of TGFβ stimulated genes and correlates with a loss of active epigenetic marks (H3K4me3 and H3K27ac) at these genomic regions. These observations argue for a dependency of TGFβ target activation on PHF13. Furthermore, PHF13-dependent chromatin regions are enriched in broad H3K4me3 domains and super-enhancers, which control genes critical to cancer-cell migration and invasion, such as SNAI1 and SOX9. Overall, our data indicate a functional and mechanistic correlation between PHF13 and EMT.

| S-EPMC9124206 | biostudies-literature

Differential oligomerization regulates PHF13 chromatin function and affinity [RNA-seq]

Project description:PHF13 is a H3K4me3 epigenetic reader, that modulates key chromatin processes including transcription, DNA damage response and chromatin architecture. PHF13 is found aberrantly regulated in different cancers and its misexpression alters the epigenetic landscape of key transcription factors that regulate Epithelial to Mesenchymal transition. In this study we sought to understand how PHF13’s chromatin affinity and diverse chromatin functions are intrinsically regulated. Our results show that PHF13 can oligomerize via conserved ordered regions in its N- and C- terminus increasing its chromatin valence and avidity. Impressively, a 4-fold over expression of PHF13 was sufficient to globally compact chromatin, dependent on its ordered dimerizing regions and oligomerization potential. Unexpectedly, we discovered that PHF13 can self-associate independent of its ordered domains via intrinsically disordered regions, which conversely reduced PHF13’s chromatin affinity. Our findings support that there is an intrinsic balance between PHF13’s ordered and disordered regions that regulates PHF13 chromatin affinity, and suggest that PHF13 can phase transition between polymer-polymer and liquid-liquid phase separation states to impact chromatin structure and function.

2025-05-29 | GSE289538 | GEO

Differential oligomerization regulates PHF13 chromatin function and affinity [ATAC-seq]

2025-05-29 | GSE289539 | GEO

PHF13 interacts with EZH2 in Panc1 cells

Project description:PHF13 interacts with EZH2 in Panc1 cells

2022-05-25 | GSE180064 | GEO

PHF13 Activates Enhancers to Promote TGFb-Induced Epithelial-to-Mesenchymal Transition

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-05-25 | GSE164824 | GEO

Genome-wide expression profiles from mouse Phf13 wildtype and knockout testes

Project description:We report expression profiles for mouse testes carrying a Phf13 knockout in comparison to wildtype testes. Upregulation of X- and Y-linked genes is evident after loss of PHF13.

2018-09-01 | GSE78917 | GEO

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