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The CLASSY family controls tissue-specific DNA methylation patterns in Arabidopsis

ABSTRACT: The CLASSY family controls tissue-specific DNA methylation patterns in Arabidopsis

PROVIDER: PRJNA692748 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR13404100.fastq.gz	Fastqsanger.gz
	SRR13404400.fastq.gz	Fastqsanger.gz
	SRR13450900.fastq.gz	Fastqsanger.gz
	SRR13404101.fastq.gz	Fastqsanger.gz
	SRR13404401.fastq.gz	Fastqsanger.gz

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Project description:DNA methylation alters the epigenetic landscape of the genome, plays critical roles in regulating gene expression, and ensures transposon silencing. As evidenced by the numerous defects associated with aberrant DNA methylation landscapes, establishing proper tissue-specific methylation patterns is critical. Yet, how such differences arise remains a largely open question in both plants and animals. Here we demonstrate that four CLASSY proteins (CLSY1-4), which are differentially expressed during plant development, play major roles in controlling tissue-specific DNA methylation patterns. Depending on the tissue, the genetic requirements for specific CLSYs differ significantly and on a global scale, certain clsy mutants are sufficient to largely shift the epigenetic landscape between tissues. Together, these findings not only reveal substantial epigenetic diversity between tissues, but assign these changes to specific CLSY proteins, revealing how locus-specific targeting combined with tissue-specific expression enables the CLSYs to generate epigenetic diversity during plant development.

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The CLASSY family controls tissue-specific DNA methylation patterns in Arabidopsis.

Project description:DNA methylation shapes the epigenetic landscape of the genome, plays critical roles in regulating gene expression, and ensures transposon silencing. As is evidenced by the numerous defects associated with aberrant DNA methylation landscapes, establishing proper tissue-specific methylation patterns is critical. Yet, how such differences arise remains a largely open question in both plants and animals. Here we demonstrate that CLASSY1-4 (CLSY1-4), four locus-specific regulators of DNA methylation, also control tissue-specific methylation patterns, with the most striking pattern observed in ovules where CLSY3 and CLSY4 control DNA methylation at loci with a highly conserved DNA motif. On a more global scale, we demonstrate that specific clsy mutants are sufficient to shift the epigenetic landscape between tissues. Together, these findings reveal substantial epigenetic diversity between tissues and assign these changes to specific CLSY proteins, elucidating how locus-specific targeting combined with tissue-specific expression enables the CLSYs to generate epigenetic diversity during plant development.

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The CLASSY family controls tissue-specific DNA methylation patterns in Arabidopsis

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