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Integrated study of the circRNA, lncRNA, mRNA and miRNA networks in testicular heat exposure

ABSTRACT: Integrated study of the circRNA, lncRNA, mRNA and miRNA networks in testicular heat exposure

PROVIDER: PRJNA695494 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR13571056_1.fastq.gz	Fastqsanger.gz
	SRR13571056_2.fastq.gz	Fastqsanger.gz
	SRR13571057_1.fastq.gz	Fastqsanger.gz
	SRR13571057_2.fastq.gz	Fastqsanger.gz
	SRR13571058_1.fastq.gz	Fastqsanger.gz

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Integrated study of the circRNA, lncRNA and mRNA networks in testicular heat exposure

Project description:The World Health Organization has recognized testicular function with temperature dependence. Testicular heat exposure caused by occupational factors, lifestyle and clinical disease, etc., can lead to different degrees of reproductive obstacles. The aim of this study is to reveal the transcriptional regulatory network and their potential crucial roles in testicular heat exposure. After passing quality control, the high throughput sequencing data of mouse testicular tissue for scrotum heat exposure and control group were carried out various analyses including differentially expressed transcriptome exploration, Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) and network regulation. Differential transcriptome expression analysis revealed that 172 circRNA (91 upregulation and 81 downregulation), 465 lncRNA (96 upregulation and 369 downregulation) and 2721 mRNA (2003 upregulation and 718 downregulation) were identified as significant differential expression in the mouse testicular tissue of heat exposure compared with control group using the cut-off of log2fold change >= 0.585, p value <= 0.05 and q value <= 1.00. Through GO term analysis, differentially expressed lncRNA and mRNA may play important functions in negative regulation of cellular process [GO:0048523], meiotic cell cycle [GO:0051321], cytoplasm [GO:0005737], membrane raft [GO:0045121], amide binding [GO:0033218], extracellular matrix binding [GO: 0050840]. KEGG pathway analysis of differentially expressed lncRNA and mRNA can be classified into MAPK signaling [mmu04010], purine metabolism [mmu00230], homologous recombination [mmu03440], RNA transport [mmu03013], nod-like receptor signaling pathway [mmu04621]. This research provides high throughput sequencing data of transcriptome in testicular heat exposure model and lays the foundation for further study on the circRNA and lncRNA in male reproductive diseases related to elevated testicular temperature.

2021-01-29 | GSE165696 | GEO

Integrated study of the circRNA, lncRNA and mRNA networks in testicular heat exposure

Project description:Integrated study of the circRNA, lncRNA and mRNA networks in testicular heat exposure

| PRJNA695496 | ENA

Integrated study of the miRNA networks in testicular heat exposure

2021-01-29 | GSE165697 | GEO

Integrated study of the miRNA networks in testicular heat exposure

Project description:Integrated study of the miRNA networks in testicular heat exposure

| PRJNA695497 | ENA

Integrated study of the circRNA, lncRNA, mRNA and miRNA networks in testicular heat exposure

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-01-29 | GSE165698 | GEO

The expression profile of circRNA, lncRNA and mRNA in the testis of STZ-induced diabetic rats

Project description:The number of patients with diabetes is increasing worldwide. Diabetic testicular damage can cause spermiogenesis disorders and sexual dysfunction. We thus explored the role of circRNA, lncRNA and mRNA in diabetic testicular damage, and revealed that they could serve as effective prevention and treatment therapeutic targets. Streptozotocin (STZ) was used to generate a rat model of type 2 diabetes. Rat testicular tissues were used for circRNA, lncRNA and mRNA sequencing.

2021-03-17 | GSE169130 | GEO

Effect of heat stress on mouse testicular peritubular myoid cells [RNA-seq]

Project description:We performed RNA-Seq of untreated testicular peritubular myoid cells (NC_1, NC_2, NC_3), and peritubular myoid cells that were collected 1 hour (H1_1, H1_2, H1_3) and 6 hours (H6_1, H6_2, H6_3) after heat treatment using BGISEQ-500 platform (BGI, China).

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Effect of heat stress on mouse testicular peritubular myoid cells [miRNA-seq]

Project description:We performed miRNA-Seq of untreated testicular peritubular myoid cells (NC_1, NC_2, NC_3), and peritubular myoid cells that were collected 1 hour (H1_1, H1_2, H1_3) and 6 hours (H6_1, H6_2, H6_3) after heat treatment using BGISEQ-500 platform (BGI, China).

2019-01-24 | GSE125634 | GEO

Gut microbiota regulates tumor via circRNA/miRNA networks

Project description:Gut microbiota regulates tumor via circRNA/miRNA networks

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Integrated analysis of circRNA-miRNA-mRNA ceRNA network responses to heat stress in rainbow trout (Oncorhynchus mykiss) liver

Project description:With the intensification of global warming, rainbow trout is suffering from varying degrees thermal stimulation, heat stress may cause pathological signs or diseases by reducing the immune roles and then lead to mass mortality, so high temperatures severely restrict the development of its aquaculture. Understanding the molecular regulation mechanism of rainbow trout under heat stress is used to take measures to relieve symptoms. We performed multiple transcriptomic analysis of liver tissues from rainbow trout under heat stress (24 °C) and control conditions (18 °C) to identify circRNAs, miRNAs and mRNAs. Changes of non-specific immune parameters revealed that strong stress response of rainbow trout is caused in 24 °C. A total of 324 DEcircRNAs, 105 DEmiRNAs, and 1885 DEmRNAs were identified from six libraries, and ceRNA regulatory network is constructed. 301 circRNA–miRNA and 51 miRNA–mRNA negative correlation pairs were screened from ceRNA regulatory network, and predicted three regulatory correlation pairs that novel_circ_003889 - novel-m0674-3p - hsp90ab1, novel_circ_002325 - miR-18-y - HSPA13 and novel_circ_002446 - novel-m0556-3p - hsp70. Some genes involved in metabolic process, biological regulation or response to stimulus are highly induced at high temperatures. Several important pathways involved in heat stress were characterized, such as Protein processing in endoplasmic reticulum (ER), Estrogen signaling pathway, HIF-1 signaling pathway, etc. These results extend our understanding of the molecular mechanisms of heat stress response and expected to provide a novel insight into develop strategies for relieve heat stress.

2019-11-08 | GSE140112 | GEO

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