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The developmental impacts of natural selection on human pelvic morphology [ATAC-seq]

ABSTRACT: The developmental impacts of natural selection on human pelvic morphology [ATAC-seq]

PROVIDER: PRJNA698615 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR13604003_1.fastq.gz	Fastqsanger.gz
	SRR13604003_2.fastq.gz	Fastqsanger.gz
	SRR13604004_1.fastq.gz	Fastqsanger.gz
	SRR13604004_2.fastq.gz	Fastqsanger.gz
	SRR13604005.fastq.gz	Fastqsanger.gz

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The developmental impacts of natural selection on human pelvic morphology

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The developmental impacts of natural selection on human pelvic morphology.

Project description:Evolutionary responses to selection for bipedalism and childbirth have shaped the human pelvis, a structure that differs substantially from that in apes. Morphology related to these factors is present by birth, yet the developmental-genetic mechanisms governing pelvic shape remain largely unknown. Here, we pinpoint and characterize a key gestational window when human-specific pelvic morphology becomes recognizable, as the ilium and the entire pelvis acquire traits essential for human walking and birth. We next use functional genomics to molecularly characterize chondrocytes from different pelvic subelements during this window to reveal their developmental-genetic architectures. We then find notable evidence of ancient selection and genetic constraint on regulatory sequences involved in ilium expansion and growth, findings complemented by our phenotypic analyses showing that variation in iliac traits is reduced in humans compared to African apes. Our datasets provide important resources for musculoskeletal biology and begin to elucidate developmental mechanisms that shape human-specific morphology.

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The developmental impacts of natural selection on human pelvic morphology [ATAC-seq]

Project description:We investigate the genetic architecture of pelvis development at the regulatory and transcriptomic level.

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Aspergillus fumigatus Colony Biofilm Morphology Impacts Hypoxia Fitness, Inflammation, and Disease Progression

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DNA supercoiling impacts alternative transcription start site selection in yeast

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Gene expression profile in pelvic organ prolapse

Project description:Introduction and Hypothesis: Identify processes contributing to pelvic organ prolapse (POP) by transcriptional profiling of pelvic connective tissue in conjunction with light microscopy. Methods: We performed a frequency matched case-control study of women undergoing hysterectomy. Total RNA, extracted from uterosacral and round ligament samples used to generate labeled cRNA, was hybridized to microarrays and analyzed for the expression of 32,878 genes. Significance Analysis of Microarrays, (Stanford University, CA), identified differentially expressed genes used for ontoanalysis, and quantitative PCR (qPCR) confirmed results. Light microscopy confirmed tissue type and assessed inflammatory infiltration. Results: The analysis of thirty-four arrays revealed 249 differentially expressed genes with fold changes larger than 1.5 fold and false discovery rates M-bM-^IM-$5.2%. Immunity and Defense was the most significant biological process differentially expressed in POP. Selected qPCR confirmed 4 genes. Light microscopy showed no inflammatory infiltrates. Conclusions: Genes enriched for Immunity and Defense contribute to POP independent of inflammatory infiltrates. Keywords: whole tissue (endopelvic fascia) type comparison This was a group matched case control study of 8 women with pelvic organ prolapse versus 9 non-prolapse controls, both undergoing hysterectomy for benign conditions. Two separate pelvic support tissues were collected from each patient. The uterosacral ligament and round ligament tissue was removed at the time of hysterectomy, RNA was extracted and ABI whole genome chips used to identify differences in expression profiles of individual samples. Various ethnic groups, age groups and menopausal status were included.

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DNA supercoiling impacts alternative transcription start site selection in yeast

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2025-03-24 | GSE292782 | GEO

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