Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Inherent genomic properties underlie the epigenomic heterogeneity of human induced pluripotent stem cells [WGBS]

ABSTRACT: Inherent genomic properties underlie the epigenomic heterogeneity of human induced pluripotent stem cells [WGBS]

PROVIDER: PRJNA699444 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR13627344.fastq.gz	Fastqsanger.gz
	SRR13627345.fastq.gz	Fastqsanger.gz
	SRR13627346.fastq.gz	Fastqsanger.gz
	SRR13627347.fastq.gz	Fastqsanger.gz
	SRR13627348.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 24

Similar Datasets

Inherent genomic properties underlie the epigenomic heterogeneity of human induced pluripotent stem cells

Project description:Inherent genomic properties underlie the epigenomic heterogeneity of human induced pluripotent stem cells

| PRJNA698386 | ENA

Inherent genomic properties underlie the epigenomic heterogeneity of human induced pluripotent stem cells [WGBS]

Project description:Human induced pluripotent stem cells (hiPSCs) show variable differentiation potential due to their epigenomic heterogeneity, whose extent/attributes remain unclear, except for well-studied elements/chromosomes such as imprints and the X chromosomes. Here, we show that seven hiPSC lines with variable germline potential exhibit substantial epigenomic heterogeneity, despite their uniform transcriptomes. Nearly a quarter of autosomal regions bear potentially differential chromatin modifications, with promoters/CpG islands for H3K27me3/H2AK119ub1 and evolutionarily young retrotransposons for H3K4me3. We identify 145 large autosomal blocks (≥100 kb) with differential H3K9me3 enrichment, many of which are lamina-associated domains (LADs) in somatic, but not in embryonic stem cells. A majority of these epigenomic heterogeneities are independent of genetic variations. We identify an X-chromosome state with chromosome-wide H3K9me3 that stably prevents X-chromosome erosion. Importantly, the germline potential of female hiPSCs correlates with X-chromosome inactivation. We propose that inherent genomic properties, including CpG density, transposons, and LADs, engender epigenomic heterogeneity in hiPSCs.

2021-11-03 | GSE166138 | GEO

Inherent genomic properties underlie the epigenomic heterogeneity of human induced pluripotent stem cells [RNA-seq]

Project description:Inherent genomic properties underlie the epigenomic heterogeneity of human induced pluripotent stem cells [RNA-seq]

| PRJNA698387 | ENA

Inherent genomic properties underlie the epigenomic heterogeneity of human induced pluripotent stem cells [ChIP-seq]

Project description:Inherent genomic properties underlie the epigenomic heterogeneity of human induced pluripotent stem cells [ChIP-seq]

| PRJNA698388 | ENA

Inherent genomic properties underlie the epigenomic heterogeneity of human induced pluripotent stem cells [RNA-seq]

2021-11-03 | GSE165868 | GEO

Inherent genomic properties underlie the epigenomic heterogeneity of human induced pluripotent stem cells [ChIP-seq]

2021-11-03 | GSE165867 | GEO

Inherent genomic properties underlie the epigenomic heterogeneity of human induced pluripotent stem cells

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-11-03 | GSE165869 | GEO

Distinct epigenomic landscapes underlie tissue-specific memory T cell differentiation

Project description:Distinct epigenomic landscapes underlie tissue-specific memory T cell differentiation

| PRJNA1018975 | ENA

Distinct epigenomic landscapes underlie tissue-specific memory T cell differentiation

Project description:Distinct epigenomic landscapes underlie tissue-specific memory T cell differentiation

| PRJNA1237795 | ENA

PCGP2 RMS WGBS - samples

Project description:WGBS files accompanying the paper titled "Identification of Therapeutic Targets in Rhabdomyosarcoma Through Integrated Genomic, Epigenomic, and Proteomic Analyses".

| EGAD00001004315 | EGA

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data