Project description:RIVUR Trial participants had Agilent 1M probe and or Nimblegen 2.1M probe aCGH performed on genomic DNA. The study was designed to discover DNA copy number variations in genes critical in kidney/urinary tract development and urinary tract infection susceptibility. Reference DNA used is a single male sample
Project description:Pseudomonas aeruginosa is one of the most frequent pathogen dominant in complicated urinary tract infections (UTI). To unravel the adaptation strategies of P. aeruginosa to the conditions in the urinary tract and to define the underlying regulatory network an artificial growth system mimicking the conditions in the urinary tract was established. Transcriptome analyses were used to investigate the physiological status of P. aeruginosa under this conditions.
Project description:We profiled both fractions of the urinary proteome for 33 human subjects with varied pathologies such as urinary tract infection (UTI), urogenital injury and commensal bacteria colonization. Using a LC-MS/MS based metaproteomic approach, we identified 5,327 non-redundant human proteins, 2,638 and 4,379 of which were associated with soluble urine (SU) and urinary pellet (UP) fractions, respectively, and approximately 1,206 non-redundant protein orthology groups derived from pathogens and commensal organisms of the urogenital tract
2018-05-24 | PXD002533 | Pride
Project description:Archaeal microbiota in the human urinary tract
