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NiV infection transcriptomics profile on HEK29T cells

ABSTRACT: NiV infection transcriptomics profile on HEK29T cells

PROVIDER: PRJNA701646 | ENA |

REPOSITORIES: ENA

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NiV infection transcriptomics profile on HEK29T cells

Project description:To delineate cellular processes involved in NiV infection, we have employed whole genome microarray expression profiling as a discovery platform to identify the upregulated and downregulated genes. Total RNA was collected from infected cells and uninfected controls. Cy3 labeled cRNA is used for hybridization platform Agilent Human 4 x 44K gene expression array.

2025-02-01 | GSE166707 | GEO

NiV genes F, G, and FG combination transfection transcriptomics profile on HEK293T cells

Project description:NiV genes F, G, and FG combination transfection transcriptomics profile on HEK293T cells

| PRJNA701630 | ENA

NiV and HeV virus like particles (VLPs) were used on HEK293T cells to determine transcriptomics profile

Project description:NiV and HeV virus like particles (VLPs) were used on HEK293T cells to determine transcriptomics profile

| PRJNA701639 | ENA

NiV genes F, G, and FG combination transfection transcriptomics profile on HEK293T cells

Project description:To delineate cellular processes involved in NiV F, G, and FG combination, we have employed whole genome microarray expression profiling as a discovery platform to identify the upregulated and downregulated genes. Total RNA was collected from transfected cells and untransfected controls. Cy3 labeled cRNA is used for hybridization platform Agilent Human 4 x 44K gene expression array.

2025-02-01 | GSE166698 | GEO

Analysis of the early transcriptome signature of Nipah virus infection in primary endothelial cells

Project description:Nipah virus (NiV) is a recently emerged zoonotic Paramyxovirus that causes regular outbreaks in East Asia with mortality rate exceeding 75%. Major cellular targets of NiV infection are endothelial cells and neurons. To better understand virus-host interaction, we analysed the transcriptome profile of NiV infection in primary human umbilical vein endothelial cells. We found that NiV infection strongly induces genes involved in interferon response in endothelial cells. Among the top ten upregulated genes, we identified the chemokine CXCL10 (interferon-induced protein 10, IP-10), an important chemoattractant involved in the generation of inflammatory immune response and neurotoxicity. We performed microarray gene expression profiling of NiV infected HUVEC cell (2 replicates) and of uninfected HUVEC cell (2 replicates).

2012-08-24 | E-GEOD-32902 | biostudies-arrayexpress

NiV and HeV virus like particles (VLPs) were used on HEK293T cells to determine transcriptomics profile

Project description:To delineate cellular processes involved in NiV and HeV VLPs, we have employed whole genome microarray expression profiling as a discovery platform to identify the upregulated and downregulated genes. Total RNA was collected from transfected cells and untransfected controls. Cy3 labeled cRNA is used for hybridization platform Agilent Human 4 x 44K gene expression array.

2025-02-01 | GSE166702 | GEO

Transcriptomics profile of NiV genes F, G, M and combinations on HEK293T cells using transfection at 44 h

Project description:Transcriptomics profile of NiV genes F, G, M and combinations on HEK293T cells using transfection at 44 h

| PRJNA701643 | ENA

Analysis of the early transcriptome signature of Nipah virus infection in primary endothelial cells

2012-08-24 | GSE32902 | GEO

Transcriptomics profile of NiV genes F, G, M and combinations on HEK293T cells using transfection at 44 h

Project description:To delineate cellular processes involved in NiV F, G, M, and combinations, we have employed whole genome microarray expression profiling as a discovery platform to identify the upregulated and downregulated genes. Total RNA was collected from transfected cells and untransfected controls. Cy3 labeled cRNA is used for hybridization platform Agilent Human 4 x 44K gene expression array.

2025-02-01 | GSE166706 | GEO

Analysis of the early transcriptome signature of infection of primary endothelial cells by Nipah virus vs. Nipah virus deleted for the expression of non-structural C protein

Project description:Nipah virus (NiV) is a highly pathogenic, negative strand RNA paramyxovirus that has recently emerged from flying foxes to cause serious human disease. To study the poorly-understood role of nonstructural NiV proteins in NiV pathogenesis, we generated recombinant viruse lacking the expression of accesory NiV C protein (NiVM-bM-^HM-^FC). To analyse the molecular basis of NiVM-bM-^HM-^FC attenuation we have used the gene microarray approach to study early changes of gene expression in infected primary human endothelial cells, which is a major cellular target of human NiV infection. We performed microarray gene expression profiling of NiV infected HUVEC cell (2 replicates), of uninfected HUVEC cell (2 replicates) and of NiVM-bM-^HM-^FC infected HUVEC cell (2 replicates).

2012-10-01 | E-GEOD-33133 | biostudies-arrayexpress

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