Single Cell RNA-Seq of PBMC from COVID-19 patients and Control subjects
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA702537 | ENA |
REPOSITORIES: ENA
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| SRR13734384.fastq.gz | Fastqsanger.gz | |||
| SRR13734385.fastq.gz | Fastqsanger.gz | |||
| SRR13734386.fastq.gz | Fastqsanger.gz | |||
| SRR13734387.fastq.gz | Fastqsanger.gz | |||
| SRR13734388.fastq.gz | Fastqsanger.gz |
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Project description:Immune characteristics associated with Coronavirus Disease-2019 (COVID-19) severity are currently unclear. We characterized bronchoalveolar lavage fluid (BALF) immune cells from patients with varying severity of COVID-19 disease and from healthy subjects using single-cell RNA-sequencing. Proinflammatory monocyte-derived macrophages were abundant in the BALF from severe COVID-9 patients. Moderate cases were characterized by the presence of highly clonally expanded tissue-resident CD8+ T cells. This atlas of the bronchoalveolar immune-microenvironment suggests potential mechanisms underlying pathogenesis and recovery in COVID-19.
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