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ABSTRACT: Pooled whole-genome sequencing of house mouse (Mus musculus) populations

PROVIDER: PRJNA702596 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR13735263_1.fastq.gz	Fastqsanger.gz
	SRR13735263_2.fastq.gz	Fastqsanger.gz
	SRR13735264_1.fastq.gz	Fastqsanger.gz
	SRR13735264_2.fastq.gz	Fastqsanger.gz
	SRR13735265_1.fastq.gz	Fastqsanger.gz

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Variation in mouse chemical signals is genetically controlled and environmentally modulated

Project description:Urine proteomes of the house mouse (Mus musculus musculus, M. m. domesticus, M. m. castaneus).

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Project description:Whole-genome resequencing data (pool-seq) of house mouse (Mus musculus) populations

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Project description:Whole-genome resequencing data (pool-seq) of house mouse (Mus musculus) populations

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Genome-wide analysis of alternative splicing evolution among Mus subspecies

Project description:We studied the evolution of alternative splicing in the early stages of species divergence in the house mouse. We sequenced the testis transcriptomes of three Mus musculus subspecies and Mus spretus using Illumina technology. On the basis of a genome-wide analysis of read coverage differences among subspecies, we identified several hundred candidate alternatively spliced regions.

2010-02-28 | E-GEOD-18905 | biostudies-arrayexpress

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Project description:Mus musculus (house mouse)

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Gene expression between high and low altitude Mus musculus domesticus

Project description:Analysis of gene expression profiles is an attractive method for discovering how animals respond to environmental challenges in nature. Compared to low altitudes, high altitudes are characterized by reduced partial pressures of oxygen (hypoxia) and cooler ambient temperatures To better understand how mammals cope with high altitudes, we trapped wild house mice (Mus musculus domesticus) from 3 populations in La Paz, Bolivia (3000 - 3600 m) and 3 populations in Lima, Peru (0 M-bM-^@M-^S 200 m). Affymetrix GeneChipM-BM-. Mouse Genome 430 2.0 Arrays were use to measure mRNA abundance in the livers of these mice. Eighteen male house mice were trapped from three different locations (3 mice per location)at high alttiude (La Paz, Bolivia, 3600 m) and from three locations at low altiditude (Lima, Peru, 100 m). Total mRNA was extracted from the livers and used for hybridization of Affymetrix GeneChip Mouse expression set 420.

2011-05-06 | E-GEOD-29097 | biostudies-arrayexpress

Comparison of transcriptomic profiles in natural populations of rodents (house mouse and black rat) along invasion routes in Senegal

Project description:We compared gene expression proﬁles between anciently and recently established populations of two major invading species, the black rat Rattus rattus and the house mouse Mus musculus musculus, in Senegal. Transcriptome analyses revealed respectively 364 and 83 differentially expressed genes along the mouse and rat invasion routes. Among them, 10 and 15% were annotated with functions related to immunity. All immune-related genes detected along the mouse invasion route were over-expressed at the invasion front. Genes of the complement activation pathway were over-represented. Results were less straightforward when considering the black rat. No particular immune pathway was over-represented. In conclusion, we revealed changes in transcriptomic profiles along invasion routes. Patterns differed between invaders. They could potentially be driven by increased infection risks at invasion front for the house mouse and trade-offs between immune responses for the black rat. Our results provide a first step in identifying the immune ecoevolutionary processes potentially involved in invasion success.

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Molecular complexity of the major urinary protein system of the Norway rat, Rattus norvegicus C4PR_LIV

Project description:Major urinary proteins (MUP) are the major component of the urinary protein fraction in house mice (Mus spp.) and rats (Rattus spp.). The structure, polymorphism and functions of these lipocalins have been well described in the western European house mouse (Mus musculus domesticus), clarifying their role in semiochemical communication. The complexity of these roles in the mouse raises the question of similar functions in other rodents, including the Norway rat, Rattus norvegicus. Norway rats express MUPs in urine but information about specific MUP isoform sequences and functions is limited. In this study, we present a detailed molecular characterization of the MUP proteoforms expressed in the urine of two laboratory strains, Wistar Han and Brown Norway, and wild caught animals, using a combination of manual gene annotation, intact protein mass spectrometry and bottom-up mass spectrometry-based proteomic approaches. Detailed sequencing of the urinary MUP isoforms reveals a less complex pattern of primary sequence polymorphism in the rat than the mouse. However, rat MUPs exhibit added complexity in the form of post-translational modifications, including the phosphorylation of Ser4 in some isoforms, and exoproteolytic trimming of specific isoforms.

2019-08-01 | PXD013986 | Pride

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