Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Anti-inflammatory effect of grape proanthocyandins (PAC) in vitro.

ABSTRACT: Anti-inflammatory effect of grape proanthocyandins (PAC) in vitro.

PROVIDER: PRJNA702807 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Anti-inflammatory effect of grape proanthocyandins (PAC) in vitro.

Project description:PAC polymers of different degrees of polymerization (DP) were used to stimulate murine RAW macrophages.

2021-02-19 | GSE167063 | GEO

Mechanistic insights into anti-cancer properties of oligomeric proanthocyanidins from grape seeds in colorectal cancer

Project description:Although the anti-cancer properties of Oligomeric Proanthocyanidins (OPCs) from grape seeds has been well recognized, the molecular mechanisms by which they exert anti-cancer effects are poorly understood. In this study, through comprehensive RNA-sequencing based gene-expression profiling in multiple colorectal cancer cell lines, we for the first time illuminate the genome-wide effects of OPCs from grape seeds in colorectal cancer. Our data revealed that OPCs affects several key cancer-associated genes. In particular, genes involved in cell cycle and DNA replication were most significantly and consistently altered by OPCs across multiple cell lines. Intriguingly, our in vivo experiments showed that OPCs was significantly more potent at decreasing xenograft tumor growth compared to the unfractionated grape seed extract (GSE) that includes the larger polymers of proanthocyanidins. These findings were further confirmed in colorectal cancer patient-derived organoids, wherein OPCs more potently inhibited the formation of organoids compared to GSE. Further, we validated alteration of cell cycle and DNA replication associated genes in cancer cell lines, mice xenografts as well as patient-derived organoids. Overall, this study provides an unbiased and comprehensive look at the mechanisms by which OPCs exerts anti-cancer properties in colorectal cancer.

2018-02-28 | GSE109607 | GEO

Grape

Project description:Grape

| PRJEB65061 | ENA

Evaluation of PAC and FASP performance

Project description:The objective of the experiment was to compare the performance of PAC and FASP.

2024-06-16 | PXD044349 | Pride

Effect of GA on PAC and PAO1 treated Arabidopsis seeds

Project description:Effect of GA on PAC and PAO1 treated Arabidopsis seeds. Seeds were treated during 20h with paclobutrazol (PAC) or with lyophilized extracts of Pseudomonas aeruginosa liquid culture medium (PAO1). Experiments were also performed with exogenous application of gibberellic acid.

2018-06-05 | GSE115272 | GEO

Anti-inflammatory compounds in SCI

Project description:A screen of 5 anti-inflammatory compounds for their effects in explanted, cultured rat spinal cord slices. All injured (explanted) cords are cultured for 4 hrs.

2010-06-05 | E-GEOD-633 | biostudies-arrayexpress

GNPS - Anti-inflammatory diet and westen diet

Project description:Diet study comparing anti-inflammatory with western diet. Data was acquired on Orbitrap Exploris 240 with chromatographic separation on a Phenomenex polar C18 column (Kinetex 2.6 um, 100 x 2.1 mm). Reversed-phase, ESI positive.

2025-03-14 | MSV000097333 | GNPS

Anti-inflammatory properties of deep sea water in-vitro and in-vivo models of inflamed intestinal epithelium

Project description:Anti-inflammatory properties of deep sea water in-vitro and in-vivo models of inflamed intestinal epithelium

| PRJNA600251 | ENA

RNA-sequencing data of intestinal tissue of mice adminstered proanthocyanidins (PAC)

Project description:We show here the transcriptional response in the distal small intestine of mice gavaged with two different PAC fractions

2021-03-04 | GSE168138 | GEO

Msc_Fractions_Lc_Ms Grape&Olive

Project description:Analysis of Food natural products of grape pomace and olive leaves

2025-03-19 | MSV000097381 | MassIVE