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Sexual dimorphism in cancer: insights from transcriptional signatures in kidney tissues and renal cell carcinoma

ABSTRACT: Sexual dimorphism in cancer: insights from transcriptional signatures in kidney tissues and renal cell carcinoma

PROVIDER: PRJNA702991 | ENA |

REPOSITORIES: ENA

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Sexual dimorphism in cancer: insights from transcriptional signatures in kidney tissues and renal cell carcinoma

Project description:We have characterized genome-wide expression and regulatory networks of 609 renal tumors and 256 non-tumor renal tissues using the Illumina HumanHT-12 v4 Expression BeadChips. Data show remarkable sexual dimorphism at transcriptional level including sex-specific signatures associated with RCC progression and survival.

2021-02-20 | GSE167093 | GEO

Sexual dimorphism in mice

Project description:Sexual dimorphism in mice

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Dissecting Sexual Dimorphism in Aortic Valve Stenosis by Proteomics

Project description:Managing aortic valve stenosis (AVS) is challenging because of the lack of pharmacotherapies to halt/revert stenosis, deeming aortic valve replacement (AVR) the only effective treatment. AVS management is further confronted with staggering sexual dimorphism; women display more extensive fibrosis, while men present remarkably higher valve calcification. To accelerate the development of effective and sex-personalised pharmacotherapies, deeper molecular insights are needed. Hence, we aimed to characterise AVS sexual dimorphism using proteomics. Aortic valves were obtained from surgical AVR. Disease severity was assessed by echocardiography. Fifty valves (50% women) were homogenised, and the proteins were quantified by LC-MS/MS. The relevance of differentially expressed proteins (DEPs) in sexual dimorphism was appraised using protein-protein interaction (PPI) and functional enrichment analyses (FEA). DEPs were validated using immunohistochemistry, qRT-PCR and ELISA, with the aid of 30 additional independent valves.

2025-10-13 | PXD051201 | Pride

Sexual Dimorphism of Circadian Liver Transcriptome

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Hepatic BCL6 and plasma triglycerides regulate sexual dimorphism in tissue tolerance [set 2]

Project description:Hepatic gene expression shows sexual dimorphism. Here, we investigated the role of BCL6 in establishing sexual dimorphism in hepatic gene expression and created Bcl6Flox/Flox,Alb-Cre mice and performed RNAseq from livers of 4- and 8-week-old male and female Ctrl and BCL6 liver knock-out mice.

2022-10-21 | GSE138391 | GEO

Sexual dimorphism in gene expression in two species of songbirds

Project description:We have done an expression experiment studying sexual dimorphism in gene expression in two species of songbirds, the zebra finch (Teaniopigia guttata) and the common whitethroat (Sylvia communis).

2010-11-30 | E-MEXP-2914 | biostudies-arrayexpress

Sexual dimorphism in cancer: insights from transcriptional signatures in kidney tissue and renal cell carcinoma.

Project description: Not available

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Sexual dimorphism in zebrafish liver proteins

Project description:The aim of the present study was to carry out a high-throughput screening of proteins using proteomics tool to identify and quantify proteins and related biochemical pathways that orchestrate the sexual dimorphism in the liver of zebrafish. In addition, we tried to discover potential connections between the sex-biased levels of proteins in liver and hepatic diseases and regeneration via review of related literature.

2025-09-04 | PXD061886 | Pride

Deletion of Klotho enhancer deepens sexual dimorphism of gene expression without impacting female resistance to kidney injury [ChIP]

Project description:Sexual dimorphism in kidney injury markers, such as Klotho, is frequently underestimated or disregarded, as most of the preclinical research is done in male animals. Klotho is well-linked to renal health and its deletion in mice results in a severe accelerated aging-like phenotype and premature death. Here, we identified candidate Klotho enhancers and discovered their function using mice carrying deletions in the enhancer loci. Candidate Klotho enhancers were deleted using CRISPR/Cas9 genome editing. Warm ischemia-reperfusion surgery (IRI) was performed bilaterally to induce acute kidney injury and unilaterally in a fibrosis model. Using ChIP-seq and RNA-seq, we analyzed renal chromatin features and gene expression. ELISA and colorimetric assays were used to measure serum FGF23 and serum component levels. Removal of the enhancer caused more substantial reduction in Klotho mRNA levels in female mice compared to males (90 vs. 50%), supported by gene promoter marks remaining more pronounced in males. Weight, lifespan, and fertility of mice lacking the enhancers were not impacted. Only male mutant mice displayed higher Havcr1 expression after IRI than controls (mean 1048 vs. 231.4, p=0.0016). 28 days after unilateral IRI, only males displayed increased fibrosis markers, but with no difference between genotypes. Our findings reveal sexual dimorphism of Klotho gene expression and its enhancer regulation. Only male mutant mice were more susceptible to acute injury and the enhancer deletion had no impact on fibrosis. Additional investigation into the mechanisms governing Klotho regulation is imperative to reassess its effectiveness as a kidney injury marker.

2024-04-04 | GSE243944 | GEO

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