Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Enteric glial cells favor accumulation of anti-inflammatory macrophages during the resolution of muscularis inflammation

ABSTRACT: Enteric glial cells favor accumulation of anti-inflammatory macrophages during the resolution of muscularis inflammation

PROVIDER: PRJNA704686 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR13779848_1.fastq.gz	Fastqsanger.gz
	SRR13779848_2.fastq.gz	Fastqsanger.gz
	SRR13779849_1.fastq.gz	Fastqsanger.gz
	SRR13779849_2.fastq.gz	Fastqsanger.gz
	SRR13779850_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 48

Similar Datasets

Enteric glial cells favor accumulation of anti-inflammatory macrophages during the resolution of muscularis inflammation

Project description:Enteric glial cells favor accumulation of anti-inflammatory macrophages during the resolution of muscularis inflammation

| PRJNA704681 | ENA

Enteric glial cells favor accumulation of anti-inflammatory macrophages during the resolution of muscularis inflammation

Project description:Enteric glial cells favor accumulation of anti-inflammatory macrophages during the resolution of muscularis inflammation

| PRJNA704688 | ENA

Enteric glial cells favor accumulation of anti-inflammatory macrophages during the resolution of muscularis inflammation

Project description:Enteric glial cells favor accumulation of anti-inflammatory macrophages during the resolution of muscularis inflammation

| PRJNA704685 | ENA

Enteric glial cells favor accumulation of anti-inflammatory macrophages during the resolution of muscularis inflammation

Project description:Enteric glial cells favor accumulation of anti-inflammatory macrophages during the resolution of muscularis inflammation

| PRJNA704683 | ENA

Enteric glial cells favor accumulation of anti-inflammatory macrophages during the resolution of muscularis inflammation

Project description:Monocyte-derived macrophages (Mφs) are crucial regulators during muscularis inflammation. However, it is unclear which micro-environmental factors are responsible for monocyte recruitment and anti-inflammatory Mφ differentiation in this paradigm. Here, we investigate Mφ heterogeneity at different stages of muscularis inflammation and determine how environmental cues can attract and activate tissue-protective Mφs. Results showed that muscularis inflammation induced marked alterations in mononuclear phagocyte populations associated with a rapid infiltration of Ly6c+ monocytes that locally acquired unique transcriptional states. Trajectory inference analysis revealed two main pro-resolving Mφ subpopulations during the resolution of muscularis inflammation, i.e. Cd206+ MhcIIhi and Timp2+ MhcIIlo Mφs. Interestingly, we found that damage to the micro-environment upon muscularis inflammation resulted in EGC activation, which in turn stimulated monocyte infiltration and the consequent differentiation in anti-inflammatory CD206+ Mφs via CCL2 and CSF1, respectively. In addition, CSF1-CSF1R signaling was shown to be essential for the differentiation of monocytes into CD206+ Mφs and EGC proliferation during muscularis inflammation. Our study provides a comprehensive insight into pro-resolving Mφ differentiation and their regulators during muscularis inflammation. We deepened our understanding in the interaction between EGCs and Mφs, thereby highlighting pro-resolving Mφ differentiation as a potential novel therapeutic strategy for the treatment of intestinal inflammation.

2022-09-12 | GSE167463 | GEO

Enteric glial cells favor accumulation of anti-inflammatory macrophages during the resolution of muscularis inflammation

2022-09-12 | GSE167465 | GEO

Enteric glial cells favor accumulation of anti-inflammatory macrophages during the resolution of muscularis inflammation

2022-09-12 | GSE167464 | GEO

Enteric glial cells favor accumulation of anti-inflammatory macrophages during the resolution of muscularis inflammation

2022-09-12 | GSE167461 | GEO

Enteric glial cells favor accumulation of anti-inflammatory macrophages during the resolution of muscularis inflammation

2022-09-12 | GSE167460 | GEO