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Loss of the chromatin remodeler, ATRX, promotes aggressive features of osteosarcomas and activates NF-kB signaling and integrin receptor binding

ABSTRACT: Loss of the chromatin remodeler, ATRX, promotes aggressive features of osteosarcomas and activates NF-kB signaling and integrin receptor binding

PROVIDER: PRJNA704931 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR13784672.fastq.gz	Fastqsanger.gz
	SRR13784673.fastq.gz	Fastqsanger.gz
	SRR13784674.fastq.gz	Fastqsanger.gz
	SRR13784675.fastq.gz	Fastqsanger.gz
	SRR13784676.fastq.gz	Fastqsanger.gz

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Loss of the chromatin remodeler, ATRX, promotes aggressive features of osteosarcomas and activates NF-kB signaling and integrin receptor binding

Project description:Osteosarcoma (OS) is a lethal disease with few known targeted therapies. Here we show that decreased ATRX expression is associated with more aggressive tumor cell phenotypes, including increased growth, migration, invasion, and metastasis. These phenotypic changes correspond with activation of NF-κB signaling, extracellular matrix remodeling, increased integrin αvβ3 expression, and ETS family transcription factor binding. However, this increased aggression substantially sensitizes ATRX-deficient OS cells to integrin signaling inhibition. Thus, ATRX plays an important tumor suppression role in OS, and loss of function of this gene may underlie a new therapeutic vulnerability. The relationship of ATRX expression with integrin binding, NF-κB activation, and ETS family transcription factor binding has not been noted in previous studies, but may impact other known diseases with ATRX loss, including other cancers and the ATR-X alpha thalassemia mental retardation syndrome.

2022-10-12 | GSE167546 | GEO

Atrx

Project description:Rattus norvegicus Atrx, ATRX, chromatin remodeler [Source:RGD Symbol;Acc:619795], is differentially expressed in 30 experiment(s);

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Project description:Rattus norvegicus Atrx, ATRX, chromatin remodeler [Source:RGD Symbol;Acc:619795], is expressed in 6 baseline experiment(s);

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ATRX

Project description:Sus scrofa ATRX, ATRX chromatin remodeler [Source:VGNC Symbol;Acc:VGNC:85686], is expressed in 3 baseline experiment(s);

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ATRX

Project description:Monodelphis domestica ATRX, ATRX chromatin remodeler [Source:HGNC Symbol;Acc:HGNC:886], is expressed in 2 baseline experiment(s);

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Atrx

Project description:Mus musculus Atrx, ATRX, chromatin remodeler [Source:MGI Symbol;Acc:MGI:103067], is differentially expressed in 76 experiment(s);

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ATRX

Project description:Oryctolagus cuniculus ATRX, ATRX chromatin remodeler [Source:HGNC Symbol;Acc:HGNC:886], is expressed in 1 baseline experiment(s);

| ENSOCUG00000007579 | ExpressionAtlas

ATRX

Project description:Homo sapiens ATRX, ATRX chromatin remodeler [Source:HGNC Symbol;Acc:HGNC:886], is expressed in 55 baseline experiment(s);

| ENSG00000085224 | ExpressionAtlas

ATRX

Project description:Sus scrofa ATRX, ATRX chromatin remodeler [Source:VGNC Symbol;Acc:VGNC:85686], is differentially expressed in 5 experiment(s);

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ATRX

Project description:Macaca mulatta ATRX, ATRX chromatin remodeler [Source:VGNC Symbol;Acc:VGNC:70195], is expressed in 3 baseline experiment(s);

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