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Macrophages of embryonic origin function during early life to determine host iNKT cell levels at barrier surfaces II

ABSTRACT: Macrophages of embryonic origin function during early life to determine host iNKT cell levels at barrier surfaces II

PROVIDER: PRJNA705682 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR13816088.fastq.gz	Fastqsanger.gz
	SRR13816089.fastq.gz	Fastqsanger.gz
	SRR13816090.fastq.gz	Fastqsanger.gz
	SRR13816091.fastq.gz	Fastqsanger.gz
	SRR13816092.fastq.gz	Fastqsanger.gz

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Macrophages of embryonic origin function during early life to determine host iNKT cell levels at barrier surfaces

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Macrophages of embryonic origin function during early life to determine host iNKT cell levels at barrier surfaces I

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Project description:It is increasingly recognized that immune development within mucosal tissues is under the control of environmental factors during early life. However, the cellular mechanisms that underlie such temporally and regionally restrictive governance of these processes is unclear. Here, we uncover an extrathymic pathway of immune development within the colon that is controlled by embryonic, but not bone-marrow derived, macrophages which determines the ability of these organs to receive invariant natural killer T (iNKT) cells and allow them to establish local residency. Consequently, early life perturbations of fetal-derived macrophages result in persistent decreases of mucosal iNKT cells and is associated with later life susceptibility or resistance to iNKT cell associated mucosal disorders. These studies uncover a host developmental program orchestrated by ontogenically distinct macrophages that is regulated by microbiota and reveal an important post-natal function of macrophages that emerge in fetal life.

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Macrophages of embryonic origin function during early life to determine host iNKT cell levels at barrier surfaces II

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Macrophages of embryonic origin function during early life to determine host iNKT cell levels at barrier surfaces I

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Macrophages of embryonic origin function during early life to determine host iNKT cell levels at barrier surfaces

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-03-31 | GSE167975 | GEO

Mouse iNKT cell: Wild type Vs Bcl11b deficient

Project description:Transcriptional profiling of mouse iNKT cells comparing wild type and Bcl11b deficient cell. The mice were treated with 4 Î¼g of Î±-galactosylceramide. Goal was to determine the effects of transcription factor Bcl11b removal in iNKT cells. Intraperitoneal treatment with 4 Î¼g of Î±-Galactosylceramide. Two pair of wild type (BCL11b F/F VÎ±14 transgenic) and Knock out (BCL11b F/F PLZF-Cre VÎ±14 transgenic)) mice were treated. Lymphocytes from spleen and liver were enriched and stain with PBS-57 Loaded CD1d tetramer. Pure iNKT cells were collected through cell sorter.

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Project description:Transcriptional profiling of mouse iNKT cells comparing wild type and Bcl11b deficient cell. The mice were treated with 4 μg of α-galactosylceramide. Goal was to determine the effects of transcription factor Bcl11b removal in iNKT cells.

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