Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ScRNA-Seq of genetically engineered mouse model of Epithelioid Hemangioendothelioma tumors

ABSTRACT: scRNA-Seq of genetically engineered mouse model of Epithelioid Hemangioendothelioma tumors

PROVIDER: PRJNA707020 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR13865126_1.fastq.gz	Fastqsanger.gz
	SRR13865126_2.fastq.gz	Fastqsanger.gz
	SRR13865127_1.fastq.gz	Fastqsanger.gz
	SRR13865127_2.fastq.gz	Fastqsanger.gz

Items per page:

1 - 4 of 4

Similar Datasets

scRNA-Seq of genetically engineered mouse model of Epithelioid Hemangioendothelioma tumors

Project description:Epithelioid hemangioendothelioma (EHE) is a rare vascular sarcoma that is associated with a WWTR1-CAMTA1 fusion gene in greater than 90% of cases. Using an adaptation of the FLEx system, we generated a genetically engineered mouse model of EHE whereby the endogenous Wwtr1 Locus is replaced with an Wwtr1-Camta1 locus. Tumors generated from this mouse model were dissociated and a 10X genomics library preparation was performed. The barcoded library was then deep sequenced.

2021-03-25 | GSE168354 | GEO

RNA-Seq of genetically engineered mouse model of Epithelioid Hemangioendothelioma tumors

Project description:Epithelioid hemangioendothelioma (EHE) is a rare vascular sarcoma that is associated with a WWTR1-CAMTA1 fusion gene in greater than 90% of cases. Using an adaptation of the FLEx system, we generated a genetically engineered mouse model of EHE whereby the endogenous Wwtr1 Locus is replaced with an Wwtr1-Camta1 locus. RNA was isolated from the resultant tumors and from control liver tissue and RNA sequencing was performed. Cross species analysis between human and mice tumors demonstrated murine EHE maintains the defining transcriptional features of human EHE.

2021-03-25 | GSE168494 | GEO

RNA-Seq of genetically engineered mouse model of Epithelioid Hemangioendothelioma tumors

Project description:RNA-Seq of genetically engineered mouse model of Epithelioid Hemangioendothelioma tumors

| PRJNA707561 | ENA

RNA-seq of Human Epithelioid Hemangioendothelioma and genetically engineered mouse model of EHE

Project description:RNA-seq of Human Epithelioid Hemangioendothelioma and genetically engineered mouse model of EHE

| PRJNA707558 | ENA

scRNA-Seq of Cdkn2a mutant murine Epithelioid Hemangioendothelioma tumors

Project description:scRNA-Seq of Cdkn2a mutant murine Epithelioid Hemangioendothelioma tumors

| PRJNA910163 | ENA

scRNA-Seq of Cdkn2a mutant murine Epithelioid Hemangioendothelioma tumors

Project description:Epithelioid hemangioendothelioma (EHE) is a rare vascular sarcoma that is associated with a TAZ-CAMTA1 fusion in greater than 90% of cases and loss of CDKN2A in human EHE tumors is associated with late stage disease. Murine EHE tumors were created by conditionally expressing TAZ-CAMTA1 and conditionally knocking out Cdkn2a within vascular endothelium. Resultant tumors were used for single cell RNA sequencing and compared against age matched wild type mice tissue.

2022-12-16 | GSE220540 | GEO

RNA-Seq of Human Epithelioid Hemangioendothelioma

Project description:RNA-Seq of Human Epithelioid Hemangioendothelioma

| PRJNA707559 | ENA

RNA-Seq of Epithelioid Hemangioendothelioma cell lines

Project description:Epithelioid hemangioendothelioma (EHE) is a rare vascular sarcoma that is associated with a WWTR1-CAMTA1 fusion gene in greater than 90% of cases. Cell lines were generated from WWTR1-CAMTA1 positive murine EHE tumors which also harbor a loss of CDKN2A. RNA sequencing was performed on cell lines.

2022-12-16 | GSE220539 | GEO

RNA-Seq of Human Epithelioid Hemangioendothelioma

Project description:Epithelioid hemangioendothelioma (EHE) is a rare vascular sarcoma that is associated with a WWTR1-CAMTA1 fusion gene in greater than 90% of cases. We aimed to investigate the transcriptional pathways activated in EHE. Total RNA was isolated from EHE tumors from surgical resection or autopsy specimens (n=6) followed by RNA-Seq. The results of this study identified a unique transcriptional profile for EHE and helped to validate a novel murine model of EHE.

2021-03-25 | GSE168493 | GEO

RNA-Seq of Epithelioid Hemangioendothelioma cell lines

Project description:RNA-Seq of Epithelioid Hemangioendothelioma cell lines

| PRJNA910164 | ENA