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Avelumab for People With Recurrent Respiratory Papillomatosis

ABSTRACT: Avelumab for People With Recurrent Respiratory Papillomatosis

PROVIDER: PRJNA713423 | ENA |

REPOSITORIES: ENA

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Avelumab for People With Recurrent Respiratory Papillomatosis

Project description:Avelumab for People With Recurrent Respiratory Papillomatosis

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Immune Dysregulation/Tumor-Associated Gene Changes in Recurrent Respiratory Papillomatosis: A Paired Microarray Analysis

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the role of HPV11 E7 in modulating sting-dependent interferon β response in recurrent respiratory papillomatosis

Project description:recurrent respiratory papillomatosis is a rare benign tumor caused mainly by the infection of the respiratory tract epithelial cells by the human papillamavirus type 6/11.the specific mechanisms underlying the inhibition of the host's innate immune response by HPV remian unclear.For this purpose,we employed single cell RNA sequencing to analyze the states of various immune cells in RRP samples post HPV infection.

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Transcription profiling of human immune dysregulation/tumor-associated gene changes in recurrent respiratory papillomatosis

Project description:The goal of this study was to determine the differential expression of specific genes within the papilloma tissues themselves and to characterize the array of host genes that might be important in the pathophysiology of recurrent respiratory papillomatosis. Experiment Overall Design: Total RNAs from papillomas (n=12) and adjacent tissues (n=12) were analyzed by Affymetrix microarray, and the matched sets of tissues compared by Genesifter paired t-test to identify differentially expressed genes in papilloma tissues while minimizing variations that are intrinsic to individual patients.

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Bioinformatics analysis of differentially expressed genes and pathways in the development of Juvenile-Onset Recurrent Respiratory Papillomatosis

Project description:Background. Juvenile-Onset Recurrent Respiratory Papillomatosis (JORRP) is the most common form of benign respiratory tract tumor in children that characterized by high recurrence and aggressiveness. The purpose of this study was to screen the key genes and pathways of JORRP by biological information analysis and to investigate the molecular mechanisms of JORRP progression. Methods. RNA sequencing (RNA-seq) was used to identify differentially expressed genes (DEGs) in three JORRP tissues and two adjacent non-tumor tissues, which were first analyzed for gene ontology (GO) and Kyoto Gene and Genome Encyclopedia (KEGG) pathway enrichment.The protein-protein interaction (PPI) network of these DEGs was next constructed with STRING and visualized with Cytoscape software. The central genes were subsequently screened using CytoHubba, a plug-in in Cytoscape software, and finally evaluated using gene function enrichment analysis. Results. A total of 1795 DEGs were screened, including 876 up-regulated genes and 919 down-regulated genes. The up-regulated DEGs were mainly enriched in cornification, cell cycle, steroid biosynthesis and HIF-1 signaling pathway, and the down-regulated DEGs were associated with cilium movement, cell projection organization, metabolism of xenobiotics by cytochrome P450 and chemical carcinogenesis. VEGFA, CDH1, CDK1, IL1B, KIF11, HIF1A, ASPM, AURKA, CENPE, MKI67 were identified as hub genes from the PPI network, and these genes were mainly associated with spindle organization, cancers-related pathways, Th17 cell differentiation and HIF-1 signaling pathway. Conclusion. The key genes and pathways screened in this study may play a pivotal role in the development of JORRP and provide a scientific basis for future related studies.

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A Phase I Study of Adjuvant PRGN-2012 in Adult Patients with Recurrent Respiratory Papillomatosis

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Recurrent respiratory papillomatosis with lung involvement.

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