Project description:We compare the overall gene expression of transgenic mice expressing the MYC oncogene (hiMYC mice) to induce tumorigenesis in the mouse prostate with mice having transgenic expression of the microRNA miR-32 in hiMYC background to determine whether increased expression of miR-32 influences growth or phenotype in prostate adenocarcinoma in vivo.
Project description:Transcriptional profiling of dorsolateral prostate of mice with prostate-specific transgenic expression of miR-32 compared with wild type mice.
Project description:Transcriptional profiling of ventral prostate of mice with prostate-specific transgenic expression of miR-32 compared with wild type mice.
Project description:Here, an overexpressed miR-6498-5p transgenic silkworm line was constructed. Importantly, the survival rates and median lethal doses of the transgenic line were clearly higher after infection with N. bombycis.
Project description:We intend to screen altered genes after overexpression of miR-196a in HD transgenic mice. Two transgenic mouse lines were used in this study, including HD transgenic mice and HD transgenic mice overexpressing miR-196a. The mice were all at approximate 12 months of age. At this point, HD transgenic mice showed severve motor dysfunctions, whereas HD transgenic mice overexpressing miR-196a displayed mild motor dysfunctions.
Project description:Transcriptional profiling of mouse livers comparing control mice with miR-155 transgenic mice that overexpression of miR-155 in the liver