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ABSTRACT: Transcriptome analysis of hybrid snakeheads spleen

PROVIDER: PRJNA718181 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR14122655_1.fastq.gz	Fastqsanger.gz
	SRR14122655_2.fastq.gz	Fastqsanger.gz
	SRR14122656_1.fastq.gz	Fastqsanger.gz
	SRR14122656_2.fastq.gz	Fastqsanger.gz
	SRR14122657_1.fastq.gz	Fastqsanger.gz

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Project description:We reported hybrid CD4+ T cell population following influenza viru infection. The hybrid CD4+ T cells exhibit both tissue residency and follicular helper T cell features. To further charaterization, we sorted lung tissue-resident helper T (TRH or TTH) cells (CD45iv-CD4+CD44+GITR-PD1hiFR4hi), non-TRH (CD45iv-CD4+CD44+GITR-PD1lowFR4low), spleen follicalar helper T (TFH) cells (CD4+CD44+GITR-PD1hiCXCR5hi) and non-TFH cells (CD4+CD44+GITR-PD1lowCXCR5low). Then the cells were applied for RNA sequencing. At the resut, we showed tissue-residency related genes are highly enriched in lung TRH but not spleen TFH cells. And The lung TRH cells express higher levels of TFH-related genes than lung-non TRH cells. Therefore, we suggest TRH cells play a role as tissue-resident helper T cells.

2020-11-27 | GSE153226 | GEO

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