Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Intersection of Regulatory Pathways Controlling Hemostasis and Hemochorial Placentation [rat II]

ABSTRACT: Intersection of Regulatory Pathways Controlling Hemostasis and Hemochorial Placentation [rat II]

PROVIDER: PRJNA721710 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Intersection of Regulatory Pathways Controlling Hemostasis and Hemochorial Placentation

Project description:Intersection of Regulatory Pathways Controlling Hemostasis and Hemochorial Placentation

| PRJNA721709 | ENA

Intersection of Regulatory Pathways Controlling Hemostasis and Hemochorial Placentation [human]

Project description:Intersection of Regulatory Pathways Controlling Hemostasis and Hemochorial Placentation [human]

| PRJNA718820 | ENA

Intersection of Regulatory Pathways Controlling Hemostasis and Hemochorial Placentation [rat I]

Project description:Intersection of Regulatory Pathways Controlling Hemostasis and Hemochorial Placentation [rat I]

| PRJNA721711 | ENA

Intersection of Regulatory Pathways Controlling Hemostasis and Hemochorial Placentation [human]

Project description:Tissue factor pathway inhibitor (TFPI) is a prominent regulator of blood coagulation and an intriguing constituent of trophoblast cells situated at the maternal-fetal interface. The actions of TFPI extend beyond controlling hemostasis and directly affect trophoblast cell development. TFPI facilitates the differentiation of rat and human trophoblast stem cells into the invasive trophoblast/extravillous cell lineage and promotes intrauterine trophoblast invasion and trophoblast-guided uterine spiral artery remodeling at the maternal-fetal interface. Thus, TFPI is a conserved regulator of a fundamental event determining the efficacy of the hemochorial placenta.

2021-11-25 | GSE171223 | GEO

Intersection of Regulatory Pathways Controlling Hemostasis and Hemochorial Placentation [rat II]

2021-11-25 | GSE171754 | GEO

Intersection of Regulatory Pathways Controlling Hemostasis and Hemochorial Placentation [rat I]

2021-11-25 | GSE171753 | GEO

Intersection of regulatory pathways controlling hemostasis and hemochorial placentation.

Project description:Hemochorial placentation is characterized by the development of trophoblast cells specialized to interact with the uterine vascular bed. We utilized trophoblast stem (TS) cell and mutant rat models to investigate regulatory mechanisms controlling trophoblast cell development. TS cell differentiation was characterized by acquisition of transcript signatures indicative of an endothelial cell-like phenotype, which was highlighted by the expression of anticoagulation factors including tissue factor pathway inhibitor (TFPI). TFPI localized to invasive endovascular trophoblast cells of the rat placentation site. Disruption of TFPI in rat TS cells interfered with development of the endothelial cell-like endovascular trophoblast cell phenotype. Similarly, TFPI was expressed in human invasive/extravillous trophoblast (EVT) cells situated within first-trimester human placental tissues and following differentiation of human TS cells. TFPI was required for human TS cell differentiation to EVT cells. We next investigated the physiological relevance of TFPI at the placentation site. Genome-edited global TFPI loss-of-function rat models revealed critical roles for TFPI in embryonic development, resulting in homogeneous midgestation lethality prohibiting analysis of the role of TFPI as a regulator of the late-gestation wave of intrauterine trophoblast cell invasion. In vivo trophoblast-specific TFPI knockdown was compatible with pregnancy but had profound effects at the uterine-placental interface, including restriction of the depth of intrauterine trophoblast cell invasion while leading to the accumulation of natural killer cells and increased fibrin deposition. Collectively, the experimentation implicates TFPI as a conserved regulator of invasive/EVT cell development, uterine spiral artery remodeling, and hemostasis at the maternal-fetal interface.

| S-EPMC8685669 | biostudies-literature

Intersection of Regulatory Pathways Controlling Hemostasis and Hemochorial Placentation

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-11-26 | GSE171755 | GEO

AKT1-FOXO4 Axis Regulates Hemochorial Placentation

Project description:AKT1-FOXO4 Axis Regulates Hemochorial Placentation

| PRJNA847904 | ENA

AKT1-FOXO4 Axis Regulates Hemochorial Placentation [Foxo4-KD-rTSC]

Project description:AKT1-FOXO4 Axis Regulates Hemochorial Placentation [Foxo4-KD-rTSC]

| PRJNA847913 | ENA