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Genomic characterization of cisplatin response uncovers priming of cispla-tin-induced genes in a resistant cell line

ABSTRACT: Genomic characterization of cisplatin response uncovers priming of cispla-tin-induced genes in a resistant cell line

PROVIDER: PRJNA724680 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR14310032.fastq.gz	Fastqsanger.gz
	SRR14310033.fastq.gz	Fastqsanger.gz
	SRR14310034.fastq.gz	Fastqsanger.gz
	SRR14310035.fastq.gz	Fastqsanger.gz
	SRR14310036.fastq.gz	Fastqsanger.gz

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Genomic characterization of cisplatin response uncovers priming of cispla-tin-induced genes in a resistant cell line

Project description:We conducted a comprehensive genomic characterization of the cisplatin sensitive A2780 ovarian cancer cell line compared to A2780cis, its resistant derivative. The data includes eXcision Repair-sequencing (XR-seq) to map cisplatin repair,RNA-Seq to characterize gene expression and ATAC-Seq to detect changes in chromatin accessibility.

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Project description:To determine the signaling networks that are dysregulated in cisplatin-resistant non-small cell lung cancer, noncoding RNA expression data were obtained from, and compared between, the lung adenocarcinoma cell line, A549, and its cisplatin-resistant derivative, A549/CDDP. Noncoding RNA expression data from a cisplatin-sensitive lung adenocarcinoma cancer cell line (A549) were collected and compared to noncoding RNA expression data from a cisplatin-resistant cell line (A549/CDDP). 3 independent experiments were completed for both the sensitive and resistant cell lines.

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