Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Gene expression profiles of chimeric antigen receptor T cells with knockout of epigenetic genes

ABSTRACT: Gene expression profiles of chimeric antigen receptor T cells with knockout of epigenetic genes

PROVIDER: PRJNA727547 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR14432274_1.fastq.gz	Fastqsanger.gz
	SRR14432274_2.fastq.gz	Fastqsanger.gz
	SRR14432275_1.fastq.gz	Fastqsanger.gz
	SRR14432275_2.fastq.gz	Fastqsanger.gz
	SRR14432276_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 18

Similar Datasets

chimeric antigen receptor T cells with knockout

Project description:chimeric antigen receptor T cells with knockout

| PRJNA727540 | ENA

Epigenetic profiles of chimeric antigen receptor T cells with knockout of PRDM1

Project description:Persistence of infused antitumor T cells is one of the essential factors for durable therapeutic response. T cells undergo genome-wide alterations in epigenetic architecture upon repeated antigen encounter, which is inevitably accompanied by progressive T cell differentiation and loss of longevity. In this study, we explored key epigenetic factors associated with terminal T cell differentiation using CRISPR/Cas9-mediated knockout of epigenetic genes in chimeric antigen receptor (CAR)-engineered human T cells and identified PRDM1 as one of the key epigenetic genes regulating T cell differentiation. We compared epigenetic profiles of control and PRDM1-knockout CAR-T cells by ATAC-sequencing analysis.

2022-05-17 | GSE173620 | GEO

Epigenetic profiles of chimeric antigen receptor T cells with knockout of PRDM1

Project description:Epigenetic profiles of chimeric antigen receptor T cells with knockout of PRDM1

| PRJNA726408 | ENA

Epigenetic profiles of chimeric antigen receptor T cells

Project description:Epigenetic profiles of chimeric antigen receptor T cells

| PRJNA916209 | ENA

Gene expression profiles of chimeric antigen receptor T cells with knockout of epigenetic genes

Project description:Persistence of infused antitumor T cells is one of the essential factors for durable therapeutic response. T cells undergo genome-wide alterations in epigenetic architecture upon repeated antigen encounter, which is inevitably accompanied by progressive T cell differentiation and loss of longevity. In this study, we explored key epigenetic factors associated with terminal T cell differentiation using CRISPR/Cas9-mediated knockout of epigenetic genes in chimeric antigen receptor (CAR)-engineered human T cells and identified multiple key epigenetic genes. We analyzed gene expression profiles of CAR-T cells that were knocked out with the specific epigenetic genes by RNA-sequencing.

2022-05-17 | GSE173918 | GEO

Phase I exploratory clinical study of CD276-targeted chimeric antigen receptor T cells for the treatment of solid tumors

Project description:Interventions: experimental group:CD276-targeted chimeric antigen receptor T cells Primary outcome(s): SAE rate Study Design: Single arm

| 2703905 | ecrin-mdr-crc

Haplo / Allogeneic NKG2DL-targeting Chimeric Antigen Receptor-grafted γδ T Cells for Relapsed or Refractory Solid Tumour

Project description:This clinical trial is an open-label, single-centre, dose escalation, phase I study designed to investigate the safety and tolerability of Haploidentical / Allogeneic NKG2DL-targeting Chimeric Antigen Receptor-grafted Gamma Delta (γδ) T Cells (CTM-N2D) in Subjects with Relapsed or Refractory Solid Tumour. The study objectives of this phase I study are to determine the safety, activity and the safe dose of haploidentical or allogeneic NKG2DL-targeting chimeric antigen receptor-grafted γδ T cells given four times weekly in patients with relapsed or refractory solid tumors of different types.

| 2317628 | ecrin-mdr-crc

Single-cell transcriptomics of chimeric antigen receptor T-cell infusion products

Project description:Single-cell transcriptomics of chimeric antigen receptor T-cell infusion products

| PRJNA636170 | ENA

A single cell atlas of CD19 chimeric antigen receptor T cells

Project description:A single cell atlas of CD19 chimeric antigen receptor T cells

| PRJNA1009859 | ENA

Effect of Cryopreservation on Autologous Chimeric Antigen Receptor T Cell Characteristics

Project description:Effect of Cryopreservation on Autologous Chimeric Antigen Receptor T Cell Characteristics

| PRJNA667053 | ENA