Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

The molecular programs underpinning 'tolerance' and 'resistance' in health and viral infection

ABSTRACT: The molecular programs underpinning 'tolerance' and 'resistance' in health and viral infection

PROVIDER: PRJNA728967 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR14510500.fastq.gz	Fastqsanger.gz
	SRR14510600.fastq.gz	Fastqsanger.gz
	SRR14510501.fastq.gz	Fastqsanger.gz
	SRR14510601.fastq.gz	Fastqsanger.gz
	SRR14510502.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 198

Similar Datasets

The molecular programs underpinning ‘tolerance’ and ‘resistance’ in health and viral infection

Project description:The molecular programs underpinning ‘tolerance’ and ‘resistance’ in health and viral infection

| PRJNA763877 | ENA

The molecular programs underpinning 'tolerance' and 'resistance' in health and viral infection

Project description:The immune protection against invading pathogens is governed by pathogen elimination (‘resistance’) and by limitation of tissue damage that results from host-pathogen interactions (‘tolerance’). However, distinct molecular states of resistance and tolerance remain obscure. Here, we collected longitudinal lung transcriptomes and clinical phenotypes of disease severity during influenza A virus (IAV) infection across 39 genetically-distinct mouse strains (32 strains of time series data and additional 7 strains with selected time points). Using transcriptional diversity in this data, we uncovered two key programs that together describe the cellular states for resistance and tolerance. The identified programs offer an unprecedented comprehensive view on shared and distinct roles of resistance and tolerance for the regulation of immune defense – for instance, we identified an antagonistic regulation of resistance and tolerance on protein production. Importantly, the framework reveals that both inflammatory states and the healthy steady state are remarkably diverse in resistance and tolerance levels, with implications on disease severity: a baseline state (before infection) of high tolerance and low resistance results in increased severity of IAV infection. Overall, our work provides a framework for the study of resistance and tolerance that could aid in clinical diagnosis and disease management.

2022-12-27 | GSE174253 | GEO

The molecular programs underpinning ‘tolerance’ and ‘resistance’ in health and viral infection

Project description:We collected lung transcriptomes 96 hours after influenza A virus (IAV) infection across 12 genetically-distinct mouse strains (2 individuals per strain).

2022-12-27 | GSE184278 | GEO

HOPX associated molecular programs control cardiomyocyte cell states underpinning cardiac structure and function

Project description:HOPX associated molecular programs control cardiomyocyte cell states underpinning cardiac structure and function

| PRJNA702061 | ENA

Maternal emulsifier consumption programs offspring metabolic and neuropsychological health

Project description:Maternal emulsifier consumption programs offspring metabolic and neuropsychological health

| PRJNA967660 | ENA

Maternal Brown Fat Thermogenesis Programs Glucose Tolerance in the Male Offspring

Project description:Maternal Brown Fat Thermogenesis Programs Glucose Tolerance in the Male Offspring

| PRJNA606192 | ENA

Maternal Brown Fat Thermogenesis Programs Glucose Tolerance in the Male Offspring

Project description:Maternal Brown Fat Thermogenesis Programs Glucose Tolerance in the Male Offspring

| PRJNA606193 | ENA

A metabolic switch orchestrated by IL-18 and the cyclic dinucleotide cGAMP programs intestinal tolerance

Project description:Tissues are exposed to diverse inflammatory challenges that shape future inflammatory responses. While cellular metabolism regulates immune function, how metabolism programs and stabilizes immune states within tissues and tunes susceptibility to inflammation is poorly understood. Here, we describe an innate immune metabolic switch that programs long-term intestinal tolerance. Intestinal interleukin-18 (IL-18) stimulation elicited tolerogenic macrophages by preventing their proinflammatory glycolytic polarization via metabolic reprogramming to fatty acid oxidation (FAO). FAO reprogramming was triggered by IL-18 activation of SLC12A3 (NCC), leading to sodium influx, release of mitochondrial DNA, and activation of stimulator of interferon genes (STING). FAO was maintained in macrophages by a bistable switch that encoded memory of IL-18 stimulation and by intercellular positive feedback that sustained the production of macrophage-derived 2'3'-cyclic GMP-AMP (cGAMP) and epithelial-derived IL-18. Thus, a tissue-reinforced metabolic switch encodes durable immune tolerance in the gut and may enable reconstructing compromised immune tolerance in chronic inflammation.

2025-01-30 | GSE223519 | GEO

Increased viral tolerance mediates by antiviral RNA interference in bat cells

Project description:Increased viral tolerance mediates by antiviral RNA interference in bat cells

| PRJNA915074 | ENA

Increased viral tolerance mediates by antiviral RNA interference in bat cells

Project description:Bats harbor highly virulent viruses that can infect other mammals, including humans, posing questions about their immune tolerance mechanisms. Bat cells employ multiple strategies to limit virus replication and virus-induced immunopathology, but the coexistence of bats and fatal viruses remains poorly understood. Here, we investigated the antiviral RNA interference (RNAi) pathway in bat cells and discovered that they have an enhanced antiviral RNAi response, producing canonical viral small interfering RNAs (vsiRNAs) upon Sindbis virus (SINV) infection that were missing in human cells. Disruption of Dicer function resulted in increased viral load for three different RNA viruses in bat cells, indicating an interferon-independent antiviral pathway. Furthermore, our findings reveal the simultaneous engagement of Dicer and pattern-recognition receptors (PRRs), such as retinoic acid-inducible gene I (RIG-I), with double-stranded RNA, suggesting that Dicer attenuates the interferon response initiation in bat cells. These insights advance our comprehension of the distinctive strategies bats employ to coexist with viruses.

2024-07-12 | GSE221607 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data