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Comparison of Drosophila melanogaster ovarian transcriptome after germline specific knock down of Snr1 or mod(mdg4) genes

ABSTRACT: Comparison of Drosophila melanogaster ovarian transcriptome after germline specific knock down of Snr1 or mod(mdg4) genes

PROVIDER: PRJNA729042 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR14511733.fastq.gz	Fastqsanger.gz
	SRR14511734.fastq.gz	Fastqsanger.gz
	SRR14511735.fastq.gz	Fastqsanger.gz
	SRR14511736.fastq.gz	Fastqsanger.gz

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Comparison of Drosophila melanogaster ovarian transcriptome after germline specific knock down of Snr1 or mod(mdg4) genes

Project description:Transcriptomic analysis and identification of differentially expressed genes in control vs KD Drosophila melanogaster ovaries. We compared gene expression profiles in Drosophila melanogaster ovaries in which the Snr1 or the mod(mdg4) gene have been selectively knocked down by tissues specific shRNA expression.

2021-12-10 | GSE174263 | GEO

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Comparison of Drosophila melanogaster ovarian transcriptome after germline specific knock down of lid or sin3A genes

Project description:Transcriptomic analysis and identification of differentially expressed genes in wt vs KD Drosophila melanogaster ovaries. We compared gene expression profiles in Drosophila melanogaster ovaries in which the lid or the sin3A gene have been selectively knocked down by tissues specific shRNA expression.

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Project description:H3K27me3 profiles using Cleavage under targets and Release using nuclease (Cut&Run) in control and KD Drosophila melanogaster ovaries. We examined the impact on chromatin profiles in Drosophila melanogaster ovaries in which the lid, the Sin3a, the Snr1 or the mod(mdg4) gene have been selectively knocked down by tissue-specific shRNA expression. We additionally explored H3K27me3 and H3K9me3 in control and dhd mutant ovaries either carrying or not a transgene.

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2012-06-18 | GSE36393 | GEO

Distribution of Drosophila insulator proteins Mod(mdg4) and L(3)mbt in Kc cells

Project description:Here we map the localization of Mod(mdg4), including Mod(mdg4)2.2 specific and Mod(mdg4) common to all isoforms, to chromatin insulators, as well as the lethal-3 malignant brain tumor protein in Drosophila Kc cells. examination of genomic occupancy for Mod(mdg4)2.2, Mod(mdg4)BTB (all isoforms), and L(3)mbt, control samples used for Drosophila Kc were previously described (Wood, Van Bortle et al., 2011 GSE30740)

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CRISPR/Cas9 knock down line

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Mod(mdg4) variants repress telomeric retrotransposon Het-A by blocking subtelomeric enhancers

Project description:Telomeres in Drosophila are composed of sequential non-LTR retrotransposons: Het-A, TART, TAHRE. Although their expression is highly dynamic, molecular mechanism governing these retrotransposons is poorly understood. Here, we show that specific splice variants of Mod(mdg4) act as repressors of Het-A by blocking subtelomeric enhancers in ovarian somatic cells. We found that a variant, Mod(mdg4)-N, can repress Het-A expression most efficiently among variants. Mod(mdg4)-N mutant flies show elevated Het-A expression and female sterility. Further investigation revealed that Mod(mdg4)-N-binding subtelomeric sequences exhibit enhancer-blocking activity, and recruitment of RNA polymerase II (Pol II) on subtelomeres by Mod(mdg4)-N is essential for this enhancer-blocking. Moreover, Mod(mdg4)-N functions to form chromatin boundaries of higher-order chromatin conformation but this mechanism is independent with its Pol II recruitment activity observed at telomeres/subtelomeres. This study provides an unexpected link between enhancer-blocking and telomere regulation, and two different molecular mechanisms exhibited by an insulator protein to orchestrate precise gene expression.

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