Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

MicroRNAs Restrain Proliferation in BRAFV600E Melanocytic Nevi [miRNA-Seq]

ABSTRACT: microRNAs Restrain Proliferation in BRAFV600E Melanocytic Nevi [miRNA-Seq]

PROVIDER: PRJNA729640 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR14520836_1.fastq.gz	Fastqsanger.gz
	SRR14520836_2.fastq.gz	Fastqsanger.gz
	SRR14520837_1.fastq.gz	Fastqsanger.gz
	SRR14520837_2.fastq.gz	Fastqsanger.gz
	SRR14520838_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 24

Similar Datasets

microRNAs Restrain Proliferation in BRAFV600E Melanocytic Nevi

Project description:microRNAs Restrain Proliferation in BRAFV600E Melanocytic Nevi

| PRJNA729639 | ENA

microRNAs Restrain Proliferation in BRAFV600E Melanocytic Nevi [RNA-Seq]

Project description:microRNAs Restrain Proliferation in BRAFV600E Melanocytic Nevi [RNA-Seq]

| PRJNA729641 | ENA

microRNAs Restrain Proliferation in BRAFV600E Melanocytic Nevi [RNA-Seq]

Project description:We conducted small RNA sequencing on low passage human melanocytes derived from melanocytic nevi and normal skin.

2021-05-13 | GSE174372 | GEO

microRNAs Restrain Proliferation in BRAFV600E Melanocytic Nevi [miRNA-Seq]

Project description:We conducted small RNA sequencing on low passage human melanocytes derived from melanocytic nevi and normal skin.

2021-05-13 | GSE174371 | GEO

microRNAs Restrain Proliferation in BRAFV600E Melanocytic Nevi [miRNA-Seq, RNA-Seq]

Project description:microRNAs Restrain Proliferation in BRAFV600E Melanocytic Nevi [miRNA-Seq, RNA-Seq]

| PRJNA633854 | ENA

microRNAs Restrain Proliferation in BRAFV600E Melanocytic Nevi [miRNA-Seq, RNA-Seq]

Project description:We conducted small RNA sequencing on low passage human melanocytes derived from melanocytic nevi and normal skin.

2020-05-22 | GSE150849 | GEO

microRNAs Restrain Proliferation in BRAFV600E Melanocytic Nevi

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-05-13 | GSE174373 | GEO

CD4+ T cells Reject Benign Melanocytic Nevi

Project description:Human CD4+ T cells mediate spontaneous rejection of acquired benign melanocytic nevi, in the majority of cases, through a break in peripheral tolerance. For the remaining cases, nevi remain stable and do not progress to malignancy. In this experiment, we compared gene expression of post-transplant rejected nevi to stable nevi in order to better characterize their transcriptional profiles.

2021-07-08 | GSE153399 | GEO

Apoptosis, autophagy and senescence protect BRAFV600E nevi from malignant transformation

Project description:The oncogenic mutation BRAFV600E is a common event in nevi and melanomas, which are aggressive skin tumors characterized by MAPK signaling pathway activation. It has been observed that mutated benign melanocytic lesions can remain unchanged for decades, but also proliferate or undergo oncogene-induced senescence. The purpose of this study was to investigate the presence of a gene expression signature in BRAFV600E mutated nevi compared to wild-type ones, all derived from sun exposed sites. Microdissected tissues from excisional biopsies of acquired nevi were analyzed to detect the presence of BRAF and NRAS mutations and to profile whole genome expression by means of oligonucleotide microarrays. BRAFV600E mutation was evidenced in 64% of nevi, while no NRAS mutations were detected. Functional analysis of genes differentially expressed between wild-type and mutated lesions pointed out the role of oxidative stress in causing the oncogenic BRAF mutation and that the direct consequence of constitutive activation of BRAF-MEK-ERK pathway, in a benign contest, is the activation of apoptosis, autophagy and senescence. Our data also indicate that in mutated lesions, p53 plays a crucial role in the maintenance of the benign status.

2024-12-31 | GSE23976 | GEO

Deconvoluted methylation profiles discriminate between closely related melanocytic nevi

Project description:Congenital melanocytic nevi (CMN) and common acquired melanocytic nevi (AMN) are skin conditions that result from an excess of melanocytes arising during fetal development or detected postnatally. Appropriately weighted whole-genome methylation analysis can be used as a basis for further research in dermatopathology and, in this application, provides new insights into nevus biology.

2024-06-17 | GSE268769 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data