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ABSTRACT: Brain Transcriptome of Nile tilapia against Streptococcus agalactiae

PROVIDER: PRJNA736158 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR14763339_1.fastq.gz	Fastqsanger.gz
	SRR14763339_2.fastq.gz	Fastqsanger.gz
	SRR14763340_1.fastq.gz	Fastqsanger.gz
	SRR14763340_2.fastq.gz	Fastqsanger.gz
	SRR14763341_1.fastq.gz	Fastqsanger.gz

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Project description:Streptococcus agalactiae (Lancefield’s group B Streptococcus, GBS) is a major bacterial species of genus Streptococcus and has medical and veterinary importance by affecting mainly humans (Maione et al., 2005; Johri et al., 2006), cattle (Keefe, 1997) and fish (Mian et al., 2009). The GBS is the most important pathogen for the Nile tilapia, a global commodity of the aquaculture sector, causing outbreaks of septicemia and meningoencephalitis (Hernández et al., 2009; Mian et al., 2009). This study aimed to evaluate the global abundancy of proteins among the main genotypes of GBS isolated from fish identified in Brazil using a label free shotgun liquid chromatography-ultra definition mass spectrometry (LC-UDMSE) approach and to compare the differential expression of proteins identified between isolates from fish and human.

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Project description:Nile tilapia brain transcriptome

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Project description:RNA-Seq data of hybrid tilapia, Nile tilapia and blue tilapia challenged with Streptococcus agalactiae

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Project description:Transcriptome analysis of Nile tilapia (Oreochromis niloticus) liver after infection with Streptococcus agalactiae

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Characterization of elongation of the very long chain fatty acid protein 6 (elovl6) gene in male Oreochromis niloticus and its potential regulatory roles in lipid and glucose metabolism

Project description:Elongation of very long-chain fatty acids protein 6 (Elovl6) is a crucial enzyme in the synthesis of endogenous fatty acids, which participates in the energy balance and metabolic diseases. The main objective of this study was to explore the molecular characterization of elovl6 and study regulatory mechanism of elovl6 on male Nile tilapia, Oreochromis niloticus. In the present study, the full-length cDNA of Nile tilapia elovl6 was 2255 bp, comprising a 5'-UTR of 193 bp, an ORF of 810 bp, and a 3'-UTR of 1252 bp, encoding 269 amino acids that possesses the characteristic features of Elovl proteins. The transcription expression of elovl6 transcripts showed differential expression in different tissues and fed with different lipid sources diet. Antisense RNA technology was used to knock-down elovl6 in Nile tilapia. Compared with the control treatments (transfected with ultrapure water (control) or the blank expression vector (negative control)), knockdown elovl6 altered hepatic morphology, Long chain fatty acid synthesis, fatty acid oxidation, lead to excess fat deposition in the liver, ultimately cause abnormal glucose/lipid metabolism in male Nile tilapia. Transcriptome analyses (AGPAT2 knock-down vs. negative control) revealed a total of 5877 differentially expressed genes (DEGs). Transcriptome analyses revealed DEGs were greatly involved in some signaling pathways, such as PPAR signaling pathway, fatty acid degradation, glycolysis/gluconeogenesis, and insulin signaling pathway, which were related to lipid and glucose metabolism. We used qRT-PCR to verify the mRNA expression changes of 13 DEGs in related signaling pathways. Our results demonstrate that knock-down of elovl6 in tilapia blocks the synthesis of oleic acid and leads to abnormal glucose/lipid metabolism.

2025-11-01 | GSE248727 | GEO

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