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RNA-sequencing data of caecum tissue of mice infected with helminths and administered garlic extract

ABSTRACT: RNA-sequencing data of caecum tissue of mice infected with helminths and administered garlic extract

PROVIDER: PRJNA739373 | ENA |

REPOSITORIES: ENA

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RNA-sequencing data of caecum tissue of mice infected with helminths and administered garlic extract

Project description:We show here the transcriptional response in caecum tissue of mice infected with Trichuris muris for 35 days and given either garlic extract treatment or control treatment.

2021-11-02 | GSE178499 | GEO

RNA-sequencing data of macrophages exposed to LPS and/or garlic extract

Project description:We show here the transcriptional response in RAW 264.7 macrophages treated with LPS and/or a garlic extract (PTSO)

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RNA-sequencing data of CMT-93 cells exposed to LPS and/or garlic extract

Project description:We show here the transcriptional response in CMT-93 intestinal epithelial cells treated with Trichuris muris antigen and/or a garlic extract (40% PTSO-PTS).

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Transcriptomic profiling of the hypothalamus in a neonatal STZ-induced diabetes model: effects of Curcumin and Aged Garlic Extract.

Project description:Type 2 Diabetes Mellitus (T2DM) is associated with a state of chronic low-grade inflammation that severely affects the central nervous system, particularly the hypothalamus, which acts as the master regulator of energy homeostasis. This study aimed to characterize the hypothalamic transcriptomic signature in a complex murine model of T2DM induced by neonatal administration of Streptozotocin (nSTZ, 70 mg/kg) followed by a chronic High-Fat Diet (HFD, 60% kcal from fat). Given the neuroprotective properties of natural polyphenols, we evaluated the modulatory effects of Curcumin (50 mg/kg) and Aged Garlic Extract (EAE, 200 mg/kg) administered daily via oral gavage for 28 days. By employing high-throughput RNA sequencing (RNA-seq), we identified differentially expressed genes (DEGs) and perturbed molecular pathways involved in neuroinflammation, synaptic plasticity and gabaergic system. Our findings provide a comprehensive map of the gene expression changes associated with diabetic neurodegeneration and the therapeutic potential of nutraceutical interventions to restore hypothalamic function.

2026-05-04 | GSE329555 | GEO

Hypothalamic transcriptomic response to High-Fat Diet induced obesity: modulatory effects of Resveratrol, Curcumin, and Aged Garlic Extract.

Project description:Obesity is a multifaceted disorder driven by the dysregulation of homeostatic mechanisms in the hypothalamus, often resulting from dietary-induced lipotoxicity and chronic neuroinflammation. This research investigates the transcriptomic shifts in the hypothalamus during the progression of High-Fat Diet (HFD) induced obesity in juvenile male C57BL/6 mice. Mice were subjected to an 8-week HFD protocol (60% kcal from fat) starting at 8 weeks of age to establish a robust obese phenotype. We explored the therapeutic efficacy of three bioactive compounds known for their antioxidant and anti-inflammatory activities: Resveratrol (2.25 mg/kg), Curcumin (50 mg/kg), and Aged Garlic Extract (200 mg/kg), administered daily during the last four weeks of the study. Through high-throughput RNA sequencing (RNA-seq), we aim to elucidate how these compounds mitigate HFD-induced transcriptomic perturbations. This study offers critical insights into the molecular basis of obesity-related neuroinflammation and identifies specific gene clusters that can be targeted by bioactive-rich dietary strategies to counteract hypothalamic dysfunction. https://doi.org/10.3390/genes17030297

2026-04-29 | GSE329539 | GEO

Global proteome analysis of gingiva from aged garlic extract-treated ddY mice

Project description:ddY mice were orally administrated aged garlic extract (2 g/kg), and gingival tissues were collected 6 hours post-administration.

2024-10-25 | PXD053156 | JPOST Repository

Phosphorylated proteome analysis of gingiva from aged garlic extract-treated ddY mice

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Effects of aged garlic extract (AGE) and FruArg on lipopolysaccharide-induced genetic response in microglial cells using gene expression profiling

Project description:We hypothesized that aged garlic extract, and a pure compound from it, FruArg, can repress the genetic response induced by lipopolysaccharide (LPS). We applied gene expression profiling to understand the potential mechanisms of the protective effects of AGE and FruArg against LPS stress in BV-2 cells. Gene expression profiling showed that AGE repressed the transcriptome alteration induced by LPS. FruArg, as an active compound in AGE, accounted for AGE's protective effects. These results suggest that AGE and FruArg are capable of alleviating oxidative and neuroinflammatory responses stimulated by LPS in BV-2 cells.

2016-10-01 | GSE87531 | GEO

Expression data from garlic-fed mouse

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Expression data from the cerebral cortex of sugarcane top ethanolic extract (STEE)-administered SAMP8 mice, water-administered SAMP8 mice, and water-administered SAMR1 mice.

Project description:Expression data from the cerebral cortex of sugarcane top ethanolic extract (STEE)-administered SAMP8 mice, water-administered SAMP8 mice, and water-administered SAMR1 mice.

| PRJNA637056 | ENA

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