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Effects of Potassium Perchlorate on Developing Medaka Primordial Germ Cells

ABSTRACT: Effects of Potassium Perchlorate on Developing Medaka Primordial Germ Cells

PROVIDER: PRJNA739694 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR14871779_1.fastq.gz	Fastqsanger.gz
	SRR14871779_2.fastq.gz	Fastqsanger.gz
	SRR14871780_1.fastq.gz	Fastqsanger.gz
	SRR14871780_2.fastq.gz	Fastqsanger.gz
	SRR14871781_1.fastq.gz	Fastqsanger.gz

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Effects of Potassium Perchlorate on Developing Medaka Primordial Germ Cells

Project description:The present study examined the effects of 0, 10, 100, and 1000 μg/L potassium perchlorate exposure on PGCs of medaka embryos and the expression pattern of genes that maintain PGCs integrity and epigenetic processes.

2024-06-21 | GSE178587 | GEO

Vitamin C mitigates potassium perchlorate exposure-induced disruption of spermatogenesis in medaka

Project description:Potassium perchlorate (KClO4), widely used in industrial and military applications, is an emerging environmental contaminant known to disrupt thyroid function. However, its potential impact on male reproductive health remains underexplored. In this study, we investigated the testicular toxicity induced by chronic KClO4 exposure over one spermatogenic cycle of medaka (Oryzias latipes) and evaluated the ameliorative effects of vitamin C. Adult male medaka were treated with 0.01 mg/L, 10 mg/L KClO4 and 10 mg/L KClO4 plus vitamin C (3 mg/mL) for 21 days. Fertilization percentage, histological examination, and transcriptomic profiling of the testis were performed. KClO4 exposure decreased fertilization success caused disorganization of seminiferous tubules, and dysregulated spermatogenic genes in the testis. Transcriptomic analysis revealed substantial dysregulation of genes involved in cadherin and tubulin binding, chromatin remodeling, oxidative stress response, and germ cell development. Co-administration of vitamin C mitigated these effects by restoring testicular morphology, restoring fertilization rates, and partially reversing gene expression changes disrupted by potassium perchlorate exposure. The present findings suggest that vitamin C provides protective effects against perchlorate-induced testicular toxicity and highlight the need for further exploration of antioxidant-based interventions to safeguard reproductive health from perchlorate exposure.

2026-06-30 | GSE301281 | GEO

Vitamin C mitigates potassium perchlorate exposure-induced disruption of spermatogenesis in medaka

Project description:Vitamin C mitigates potassium perchlorate exposure-induced disruption of spermatogenesis in medaka

| PRJNA1284747 | ENA

Transcriptomic fingerprints of C. elegans exposed to sodium perchlorate.

Project description:The excessive perchlorate utilization as an oxidizer in rocket propellants and blasting agents had led to the contamination of surface and ground waters. This chemical is known to compete with iodine for binding to the thyroid membrane receptors potentially causing hypothyroidism and fetal retardation in pregnant women. Nevertheless, to date, its biological effects are not completely understood. We have investigated the molecular mechanisms responsive to perchlorate in the nematode C. elegans to nominate a candidate gene for further peruse in the development of a C.elegans perchlorate biosensor. Perchlorate (1 mg/mL) affected the transcriptional response of Regulation of developmental process, growth, defense mechanisms and stress response, among other biological processes.

2020-04-30 | GSE149596 | GEO

Comparison of effects of Iodine-deficiency and perchlorate on thyroid

Project description:Perchlorate, which is a ubiquitous and persistent ion, competitively interferes with iodide accumulation in the thyroid, causing iodine deficiency, which may result in reduced thyroid hormone synthesis and secretion. Human studies suggest that perchlorate presents very little risk in healthy individuals; however, the precautionary principle demands that the sensitive populations of iodine deficient adults and mothers require extra consideration. In an attempt to determine if the effects on gene expression were similar, we compared the thyroidal effects of perchlorate (10 mg/kg) treatment for 14 days in drinking water with those caused by 8 weeks of Iodine-deficiency in rats. The thyroids were collected (N=3 each group) and total mRNA was analyzed using the Affymetrix Rat Genome 230 2.0 GeneChip®. Changes in gene expression were compared with appropriate control groups. We compared the 2-fold gene changes due to I-deficiency with changes due to perchlorate treatment. 189 transcripts were changed by the Iodine-deficient diet and 722 transcripts were changed by the perchlorate treatment. 34% of the transcripts changed by the I-deficient diet were also changed by perchlorate and generally in the same direction. three specific transporter genes, AQP1, NIS, & SLC22A3 were changed by both treatments, indicating that the membrane specific changes were similar. Iodine-deficiency primarily caused changes in retinol and calcium signaling pathways and perchlorate primarily caused changes related to the accumulation of extracellular matrix proteins. This study provides evidence that perchlorate, at least at this dose level, changes more genes and changes different genes compared to iodine deficiency.

2010-11-04 | GSE25144 | GEO

Comparison of effects of Iodine-deficiency and perchlorate on thyroid

2010-11-04 | E-GEOD-25144 | biostudies-arrayexpress