Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

B-cell derived macrophage in mouse and human breast cancer macrophage

ABSTRACT: B-cell derived macrophage in mouse and human breast cancer macrophage

PROVIDER: PRJNA740180 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR14886982_1.fastq.gz	Fastqsanger.gz
	SRR14886982_2.fastq.gz	Fastqsanger.gz
	SRR14886983_1.fastq.gz	Fastqsanger.gz
	SRR14886983_2.fastq.gz	Fastqsanger.gz
	SRR14886984_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 40

Similar Datasets

Transcriptomic profiling of macrophage induced breast cancer cells

Project description:To infestigate the effect of macrophage on breast cancer cells, we treated breast cancer cells with medium from either monocyte derived macrophages or breast cancer cell medium treated monocyte derived macrophages

2022-11-14 | GSE211821 | GEO

Mouse Breast Cancer

Project description:Mouse Breast Cancer

| PRJEB2203 | ENA

Characterization of tumor-associated-macrophage of breast cancer patient-derived xenografts

Project description:Characterization of tumor-associated-macrophage of breast cancer patient-derived xenografts

| PRJNA318812 | ENA

Mouse modeling dissecting macrophage-breast cancer communication uncovered roles of PYK2 in macrophage recruitment and breast tumorigenesis

Project description:Mouse modeling dissecting macrophage-breast cancer communication uncovered roles of PYK2 in macrophage recruitment and breast tumorigenesis

| PRJNA795173 | ENA

Mouse modeling dissecting macrophage-breast cancer communication uncovered roles of PYK2 in macrophage recruitment and breast tumorigenesis

Project description:Macrophage infiltration in mammary tumors is associated with enhanced tumor progression, metastasis, and poor clinical outcome, and considered as target for therapeutic intervention. Here we used different genetic mouse models and show that ablation of the tyrosine kinase PYK2, either in breast cancer cells, only in the tumor microenvironment, or both, markedly reduced the number of infiltrating tumor macrophages and concomitantly inhibited tumor angiogenesis and tumor growth. Strikingly, PYK2 depletion only in macrophages was sufficient to induce similar effects. These phenotypic changes were associated with reduced monocyte recruitment and a substantial decrease in tumor-associated macrophages (TAMs). Mechanistically, we show that PYK2 mediates mutual communication between breast cancer cells and macrophages through critical effects on key receptor signaling. Specifically, PYK2 ablation inhibited Notch1 signaling and consequently reduced CCL2 secretion by breast cancer cells, and concurrently reduced the levels of CCR2, CXCR4, IL4R, and Stat6 activation in macrophages. These bidirectional effects modulate monocyte recruitment, macrophage polarization and tumor angiogenesis. PYK2 expression is correlated with infiltrated macrophages in breast cancer patients, and its significant effects on macrophage infiltration and their pro-tumorigenic phenotype suggest that PYK2 targeting can be utilized as an effective strategy to modulate TAMs and possibly sensitize breast cancer to immunotherapy.

2022-02-09 | GSE193168 | GEO

Macrophage reponse to triple-negative breast cancer cells in vitro

Project description:Gene expression profiling of monocyte-derived macrophage polarised by triple-negative breast cancer cell conditioned medium

2016-12-28 | GSE92927 | GEO