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The transcriptional repressor REST is a major suppressor of endocrine differentiation during pancreas organogenesis [RNA-seq]

ABSTRACT: The transcriptional repressor REST is a major suppressor of endocrine differentiation during pancreas organogenesis [RNA-seq]

PROVIDER: PRJNA742268 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR14936548_1.fastq.gz	Fastqsanger.gz
	SRR14936548_2.fastq.gz	Fastqsanger.gz
	SRR14936549_1.fastq.gz	Fastqsanger.gz
	SRR14936549_2.fastq.gz	Fastqsanger.gz
	SRR14936550_1.fastq.gz	Fastqsanger.gz

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The transcriptional repressor REST is a major suppressor of endocrine differentiation during pancreas organogenesis [RNA-seq]

Project description:Purpose: Decipher the role of REST in pancreas organogenesis and endocrine differentiation (REST RNAseq-samples E18.5 pancreas)

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The transcriptional repressor REST is a major suppressor of endocrine differentiation during pancreas organogenesis [ChIP-seq]

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The transcriptional repressor REST is a major suppressor of endocrine differentiation during pancreas organogenesis.

Project description:The transcriptional repressor REST is a major suppressor of endocrine differentiation during pancreas organogenesis.

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The transcriptional repressor REST is a major suppressor of endocrine differentiation during pancreas organogenesis [ChIP-seq]

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REST is a major negative regulator of endocrine differentiation during pancreas organogenesis.

Project description:Multiple transcription factors have been shown to promote pancreatic β-cell differentiation, yet much less is known about negative regulators. Earlier epigenomic studies suggested that the transcriptional repressor REST could be a suppressor of endocrinogenesis in the embryonic pancreas. However, pancreatic Rest knockout mice failed to show abnormal numbers of endocrine cells, suggesting that REST is not a major regulator of endocrine differentiation. Using a different conditional allele that enables profound REST inactivation, we observed a marked increase in pancreatic endocrine cell formation. REST inhibition also promoted endocrinogenesis in zebrafish and mouse early postnatal ducts and induced β-cell-specific genes in human adult duct-derived organoids. We also defined genomic sites that are bound and repressed by REST in the embryonic pancreas. Our findings show that REST-dependent inhibition ensures a balanced production of endocrine cells from embryonic pancreatic progenitors.

| S-EPMC8415321 | biostudies-literature

The transcriptional repressor REST is a major suppressor of endocrine differentiation during pancreas organogenesis.

Project description:This SuperSeries is composed of the SubSeries listed below.

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TF ChIP-seq from progenitor cell of endocrine pancreas (ENCSR901NIN)

Project description:CTCF ChIP-seq on progenitor cell of endocrine pancreas originated from progenitor cell of endocrine pancreas For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Research/ENCODE/ENCODE_Data_Use_Policy_for_External_Users_03-07-14.pdf

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Transcription profiling of cells from four developmental stages of human endocrine pancreas to define genetic pathways that regulate endocrine pancreatic development

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2006-06-30 | E-CBIL-14 | biostudies-arrayexpress

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