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Gene Expresssion Analysis of Myometrium Stem Cells Treated with CDK8/19 Inhibitor

ABSTRACT: Gene Expresssion Analysis of Myometrium Stem Cells Treated with CDK8/19 Inhibitor

PROVIDER: PRJNA744059 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR15048081.fastq.gz	Fastqsanger.gz
	SRR15048082.fastq.gz	Fastqsanger.gz
	SRR15048083.fastq.gz	Fastqsanger.gz
	SRR15048084.fastq.gz	Fastqsanger.gz
	SRR15048085.fastq.gz	Fastqsanger.gz

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Gene Expresssion Analysis of Myometrium Stem Cells Treated with CDK8/19 Inhibitor

Project description:We report the gene expression changes in myometrial stem cells after 3hr treatment with CDK8/19 inhibitor (CCT251545).

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Confirmation of cdk8/19 inhibitor selectivity and activity in colorectal cancer

Project description:The Mediator complex is an evolutionarily conserved regulator of gene expression, influencing chromatin structure and RNA polymerase II-mediated transcription. Its activity is modulated by a protein kinase module, which includes cyclin-dependent kinases 8 and 19, that phosphorylate RNA polymerase II and transcription factors to regulate gene expression. CDK8 exhibits both oncogenic and tumour-suppressive activities depending on the cellular context, while the contributions of CDK19 remain less well understood. Based on prior data with our CDK8/19 inhibitor - 3,4,5-trisubstituted pyridine compound CCT251545 - we selected the human colorectal cancer cell line COLO205 for profiling experiments. This model is highly dependent on mutant BRAF and oncogenic β-catenin-driven WNT signaling and exhibits high basal β-catenin-dependent TCF/LEF promoter activity, which is sensitive to CDK8/19 inhibition in vitro and in vivo.

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Transcriptomic analysis of the effects of CDK8 and CDK19 knockout and re-expression and selective CDK8/19 kinase inhibitor Senexin B treatment on gene expression in HEK293 cells

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Project description:RNA-Seq analysis was carried out to investigate the transcriptomic changes associated with the development of in vivo everolimus resistance and the effects of CDK8/19 inhibition on the development of resistance in MDA-MB-468 TNBC xenografts. In one study (short-term), tumor samples were collected after 30-40 days of treatment with vehicle or everolimus, when the tumor growth was still suppressed by the mTOR inhibitor. In another study (long-term), tumor samples were collected after 60-153 days of treatment with vehicle, everolimus, CDK8/19 inhibitor SNX631 or their combination, when tumors treated with everolimus but not with the drug combination developed resistance.

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Effects of CDK8/19 Mediator Kinase inhibition by Senexin B on gene expression in HEK293 cells

Project description:RNA-Seq analysis was carried out to investigate the effects of selective CDK8/19 inhibitor Senexin B on gene expression in HEK293 cells (293-WT) or the CDK8/19 double-knockout (293-dKO) derivatives.

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Project description:RNA-Seq analysis was carried out to investigate the effects of selective CDK8/19 inhibitor BI1347 and PROTAC degrader SNX7886 on gene expression in HEK293 cells (293-WT) or the CDK8/19 double-knockout (293-dKO) derivatives.

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Project description:In this study, we demonstrate that we can obtain human iPSC-derived pancreatic islet-like cells (iPICs) with comparable transcriptomic profile by using a combination of an ALK5 inhibitor and a CDK8/19 inhibitor, instead of utilizing ALK5 inhibitor II.

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