Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: Direct whole genome sequencing of Treponema pallidum from clinical specimens

PROVIDER: PRJNA744275 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR15055832_1.fastq.gz	Fastqsanger.gz
	SRR15055832_2.fastq.gz	Fastqsanger.gz
	SRR15055833_1.fastq.gz	Fastqsanger.gz
	SRR15055833_2.fastq.gz	Fastqsanger.gz
	SRR15055834_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 20

Similar Datasets

Genome-wide microRNAs analysis of peripheral blood mononuclear cells reveals elevated miR-142-3p expression as a potential biomarker for secondary syphilis

Project description:Treponema pallidum subspecies pallidum (T. pallidum) infection induces significant immune responses, resulting in tissue damage. Gene expression plays an essential role in regulating the progression of syphilis infection. However, little is known about the regulatory role of miRNAs in the immune response to T. pallidum infection. Here, we analyze the differential expression of miRNAs in peripheral blood mononuclear cells (PBMCs) between secondary syphilis (SS) patients and healthy controls and study the correlation between miRNAs expression and clinical features with bioinformatics.

2020-08-19 | GSE156421 | GEO

Treponema pallidum SS14 global proteomics

Project description:Raw data files (RAW and mzML) and Scaffold search engine files corresponding to the whole proteome analyses of the syphilis spirochete, Treponema pallidum ssp. pallidum, strain SS14.

| MSV000095818 | MassIVE

Treponema pallidum subsp. pallidum

Project description:Treponema pallidum subsp. pallidum Genome sequencing

| PRJNA271237 | ENA

Project description:Complete Genome Sequences of Two Treponema pallidum subsp. pallidum specimens from Canadian Patients

| PRJNA1257817 | ENA

MicroRNA expression profiling of peripheral blood mononuclear cells associated with syphilis

Project description:Treponema pallidum (Tp) infection evokes vigorous immune responses, resulting in tissue damage. The immune mechanism after Treponema pallidum infection is still not clear. MicroRNAs (miRNAs) have been shown, however, to influence immune cell function and consequently the generation of antibody responses during other microbe infections, but these values are unknown for Tp. In this study, we performed a comprehensive analysis of differentially expressed miRNAs in healthy persons, untreated patients with syphilis, patients in the serofast state, and serologically cured patients. MiRNAs were profiled from patient peripheral blood obtained at the time of serological diagnosis. There were 89 differentially regulated miRNA identified in total. Then both the target sequence analysis on these different miRNAs and pathway analysis were performed to identify important immune and cell signaling pathways. Following RT-qPCR confirmation, three miRNAs (hsa-miR-195-5p, hsa-miR-223-3p, hsa-miR-589-3p) showed significant difference among serofast state, and serological cure (P<0.05). Two miRNAs (hsa-miR-195-5p, hsa-miR-1204) showed significant differences among untreated patients and healthy individuals. This is the first study of miRNA expression difference in PBMC in different stages of T. pallium infection. Our study suggests that the combination of three miRNAs has great potential to serve as non-invasive biomarkers of Treponema pallidum infections, which will facilitate better diagnosis and treat of T. pallium infections.

2019-12-28 | GSE142676 | GEO

Project description:Whole genome sequencing of Treponema pallidum directly from clinical samples and rabbit cultivation

| PRJNA562373 | ENA

Treponema pallidum subsp. pallidum

Project description:Treponema pallidum subsp. pallidum Genome sequencing and assembly

| PRJNA508872 | ENA

Treponema pallidum subsp. pallidum strain:Amoy

Project description:Treponema pallidum subsp. pallidum strain:Amoy Genome sequencing

| PRJNA315615 | ENA

Treponema pallidum subsp. pallidum

Project description:Treponema pallidum subsp. pallidum Genome sequencing and assembly

| PRJNA544785 | ENA

Treponema pallidum subsp. pallidum strain:NYMC01

Project description:Treponema pallidum subsp. pallidum strain:NYMC01 Genome sequencing

| PRJNA962037 | ENA

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data