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Tcf1-CTCF cooperativity shapes genomic architecture to promote CD8+ T cell homeostasis [CTCF Cut&Run]

ABSTRACT: Tcf1-CTCF cooperativity shapes genomic architecture to promote CD8+ T cell homeostasis [CTCF Cut&Run]

PROVIDER: PRJNA744774 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR15069553_1.fastq.gz	Fastqsanger.gz
	SRR15069553_2.fastq.gz	Fastqsanger.gz
	SRR15069554_1.fastq.gz	Fastqsanger.gz
	SRR15069554_2.fastq.gz	Fastqsanger.gz
	SRR15069555_1.fastq.gz	Fastqsanger.gz

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Tcf1-CTCF cooperativity shapes genomic architecture to promote CD8+ T cell homeostasis

Project description:Tcf1-CTCF cooperativity shapes genomic architecture to promote CD8+ T cell homeostasis

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Tcf1-CTCF cooperativity shapes genomic architecture to promote CD8+ T cell homeostasis [Hi-C]

Project description:Tcf1-CTCF cooperativity shapes genomic architecture to promote CD8+ T cell homeostasis [Hi-C]

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Tcf1-CTCF cooperativity shapes genomic architecture to promote CD8+ T cell homeostasis [DNase-Seq]

Project description:Tcf1-CTCF cooperativity shapes genomic architecture to promote CD8+ T cell homeostasis [DNase-Seq]

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Tcf1-CTCF cooperativity shapes genomic architecture to promote CD8+ T cell homeostasis [RNA-Seq]

Project description:Tcf1-CTCF cooperativity shapes genomic architecture to promote CD8+ T cell homeostasis [RNA-Seq]

| PRJNA744776 | ENA

Tcf1-CTCF cooperativity shapes genomic architecture to promote CD8+ T cell homeostasis [CTCF Cut&Run]

Project description:An intricate interplay among Tcf1/Lef1, CTCF and Stat5 that orchestrates genomic architecture to coordinately promote CD8+ T cell homeostatic proliferation

2022-04-25 | GSE179723 | GEO

Tcf1-CTCF cooperativity shapes genomic architecture to promote CD8+ T cell homeostasis [Hi-C]

Project description:An intricate interplay among Tcf1/Lef1, CTCF and Stat5 that orchestrates genomic architecture to coordinately promote CD8+ T cell homeostatic proliferation

2022-04-25 | GSE179773 | GEO

Tcf1-CTCF cooperativity shapes genomic architecture to promote CD8+ T cell homeostasis [RNA-Seq]

Project description:An intricate interplay among Tcf1/Lef1, CTCF and Stat5 that orchestrates genomic architecture to coordinately promote CD8+ T cell homeostatic proliferation

2022-04-25 | GSE179725 | GEO

Tcf1-CTCF cooperativity shapes genomic architecture to promote CD8+ T cell homeostasis [DNase-Seq]

Project description:An intricate interplay among Tcf1/Lef1, CTCF and Stat5 that orchestrates genomic architecture to coordinately promote CD8+ T cell homeostatic proliferation

2022-04-25 | GSE179724 | GEO

Tcf1-CTCF cooperativity shapes genomic architecture to promote CD8<sup>+</sup> T cell homeostasis.

Project description:CD8+ T cell homeostasis is maintained by the cytokines IL-7 and IL-15. Here we show that transcription factors Tcf1 and Lef1 were intrinsically required for homeostatic proliferation of CD8+ T cells. Multiomics analyses showed that Tcf1 recruited the genome organizer CTCF and that homeostatic cytokines induced Tcf1-dependent CTCF redistribution in the CD8+ T cell genome. Hi-C coupled with network analyses indicated that Tcf1 and CTCF acted cooperatively to promote chromatin interactions and form highly connected, dynamic interaction hubs in CD8+ T cells before and after cytokine stimulation. Ablating CTCF phenocopied the proliferative defects caused by Tcf1 and Lef1 deficiency. Tcf1 and CTCF controlled a similar set of genes that regulated cell cycle progression and promoted CD8+ T cell homeostatic proliferation in vivo. These findings identified CTCF as a Tcf1 cofactor and uncovered an intricate interplay between Tcf1 and CTCF that modulates the genomic architecture of CD8+ T cells to preserve homeostasis.

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Tcf1-CTCF cooperativity shapes genomic architecture to promote CD8+ T cell homeostasis

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-04-25 | GSE179775 | GEO