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Mesenchymal Stem Cell Transplantation Attenuates Venous Stenosis of Hemodialysis Vascular Access Arteriovenous Fistula [P33 GV RAW]

ABSTRACT: Mesenchymal Stem Cell Transplantation Attenuates Venous Stenosis of Hemodialysis Vascular Access Arteriovenous Fistula [P33 GV RAW]

PROVIDER: PRJNA746075 | ENA |

REPOSITORIES: ENA

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Mesenchymal Stem Cell Transplantation Attenuates Venous Stenosis of Hemodialysis Vascular Access Arteriovenous Fistula [P33 GV RAW]

Project description:Arteriovenous fistula (AVF) is the preferred vascular access for patients undergoing hemodialysis and the majority of AVFs fail because of venous intimal hyperplasia (VNH). Results from our lab have shown that adipose tissue-derived mesenchymal stem cell (MSC) transplantation to the adventitia of the outflow vein of AVF attenuates VNH in an immunodeficient mice. in the present study efficacy of AMSCs transplantation in treating AVF failure was tested in a chronic kidney disease (CKD) followed by an AVF created in C57BL/6 mice and porcine models as described in methods. Moreover, a phase 1 trial was performed in small group of endstage renal disease (ESRD) patients who are in hemodialysis. To explore the molecular mechanisms involved in MSCs transplantation improving AVF durability, we performed RNA-seq transcriptome analysis of the outflow veins of AVFs excised from mice and Pigs the after adventitial transplantation of MSCs from the donor inbred C57BL/6 mice or pigs respectively. RNA-seq on AMSCs isolated from donor mice, pigs and from patients of Phase 1 study was performed and CD markers of MSCs were compared to assess the homogenicity of isolated AMSCs with in the species.

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Genes differently expression between human failed arteriovenous fistula (AVF) and the control

Project description:From January 1, 2018 to December 31, 2018, there were 19 patients (from four hemodialysis centers) undergoing failing arteriovenous fistula (AVF) that were resistant to endovascular therapy with extensive fistula aneurysmal change (n=4), diffuse stenosis (n=13) or poor skin condition of the forearm (n=2). While 13 of them manifested good size and quality of the outflow vein (>10 cm long, >6 mm in diameter and <6 mm under the skin, BF >600 ml/min) to create of a new AVF upstream. They have been provided with an end-to-side anastomosis of the outflow vein with the more proximal inflow artery, together with ligation of the failing downstream AVF. During the operation, the small segment adjacent to the distal healthy access was exercised for the control access (CA) sample. Until December 31, 2019, 5 of 13 patients had suffered failing AVF again, followed by the excision of segment of high-grade stenosis for the failing access (FA) samples.

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Mesenchymal Stem Cell Transplantation Attenuates Venous Stenosis of Hemodialysis Vascular Access Arteriovenous Fistula.

Project description:Mesenchymal Stem Cell Transplantation Attenuates Venous Stenosis of Hemodialysis Vascular Access Arteriovenous Fistula.

| PRJNA926618 | ENA

Mesenchymal Stem Cell Transplantation Attenuates Venous Stenosis of Hemodialysis Vascular Access Arteriovenous Fistula

Project description:Mesenchymal Stem Cell Transplantation Attenuates Venous Stenosis of Hemodialysis Vascular Access Arteriovenous Fistula

| PRJNA745979 | ENA

Fractalkine Antibody Attenuates Venous Neointimal Hyperplasia of Arteriovenous Fistula in Mice model

Project description:Fractalkine Antibody Attenuates Venous Neointimal Hyperplasia of Arteriovenous Fistula in Mice model

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