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Defining the nature of human pluripotent stem cell-derived interneurons via single cell analysis

ABSTRACT: Defining the nature of human pluripotent stem cell-derived interneurons via single cell analysis

PROVIDER: PRJNA746615 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR15142500.fastq.gz	Fastqsanger.gz
	SRR15142501.fastq.gz	Fastqsanger.gz
	SRR15142502_1.fastq.gz	Fastqsanger.gz
	SRR15142502_2.fastq.gz	Fastqsanger.gz
	SRR15142503_1.fastq.gz	Fastqsanger.gz

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Defining the nature of human pluripotent stem cell-derived interneurons via single cell analysis

Project description:Defining the nature of human pluripotent stem cell-derived interneurons via single cell analysis

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Project description:We applied single nuclei and single cell transcriptomics methods to model interneuron development with interneurons derived from human PSCs. We find that PSC-derived interneurons capture stages of development prior to mid gestation, but only represent a minority of potential subtypes that are found in the brain. Comparison of these interneurons to those found in the adult brain highlighted decreased expression of synapse-related genes, reflective of their electrophysiological immaturity. Together, these analyses provide a full characterization of PSC-derived interneurons.

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