Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Single cell transcriptional profiling of cultured developing neurons upon inflammatory challenge [in vivo]

ABSTRACT: Single cell transcriptional profiling of cultured developing neurons upon inflammatory challenge [in vivo]

PROVIDER: PRJNA747922 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR15187059.fastq.gz	Fastqsanger.gz
	SRR15187060.fastq.gz	Fastqsanger.gz
	SRR15187061.fastq.gz	Fastqsanger.gz
	SRR15187062.fastq.gz	Fastqsanger.gz

Items per page:

1 - 4 of 4

Similar Datasets

Single cell transcriptional profiling of cultured developing neurons upon inflammatory challenge

Project description:Single cell transcriptional profiling of cultured developing neurons upon inflammatory challenge

| PRJNA747918 | ENA

Single cell transcriptional profiling of cultured developing neurons upon inflammatory challenge [in vitro]

Project description:Single cell transcriptional profiling of cultured developing neurons upon inflammatory challenge [in vitro]

| PRJNA541482 | ENA

Single cell transcriptional profiling of cultured developing neurons upon inflammatory challenge [in vivo]

Project description:The communication between immune and central nervous system represents an emerging field in neuroscience with many potential consequences both in basic and translational medicine. Among the plethora of mechanisms which might be involved, it is now clear that that immune molecules released upon inflammatory state can modulate different physiological aspects of brain development, resulting in long-lasting pathological consequences which may interfere with normal behavior during adulthood. A common aspect of this immune molecule is to promote deep transcriptional changes responsible for long-term effects. Single-cell RNA sequencing is now becoming a cutting-edge technology for studying the genomic rearrangement occurring at single cell level in different experimental models, thus opening a new frontier in medicine. Here, by using primary cultured neurons as a simplified model for studying neuronal development, we study the long-term consequences of the proinflammatory cytokine interleukine-6 (IL-6) on developing neurons through a single-cell sequencing approach. Based on the immuneprofiling of the analyzed cells, we identified different neuronal and non-neuronal cell clusters whose transcriptional profile changed specifically upon the inflammatory stimulation.

2021-07-20 | GSE180344 | GEO

Single cell transcriptional profiling of cultured developing neurons upon inflammatory challenge [in vitro]

2021-05-13 | GSE130803 | GEO

Single cell transcriptional profiling of cultured developing neurons upon inflammatory challenge

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-07-20 | GSE180345 | GEO

Poly(A) RNA profiling upon Gld2 knockdown in cultured hippocampal neurons

Project description:Poly(A) RNA profiling upon Gld2 knockdown in cultured hippocampal neurons

2012-09-01 | GSE37695 | GEO

Poly(A) RNA profiling upon Gld2 knockdown in cultured hippocampal neurons

Project description:Poly(A) RNA profiling upon Gld2 knockdown in cultured hippocampal neurons Neurons transduced with scrambled and Gld2 knowdown shRNA

2012-09-01 | E-GEOD-37695 | biostudies-arrayexpress

TREM2 regulates microglial cholesterol metabolism upon chronic phagocytic challenge

Project description:TREM2 regulates microglial cholesterol metabolism upon chronic phagocytic challenge

| PRJNA540829 | ENA

Transcriptomic analyses of Aedes aegypti cultured cells upon heme exposure

Project description:Transcriptomic analyses of Aedes aegypti cultured cells upon heme exposure

| PRJNA590788 | ENA

TREM2 regulates microglial cholesterol metabolism upon chronic phagocytic challenge [bulk RNA-seq]

Project description:TREM2 regulates microglial cholesterol metabolism upon chronic phagocytic challenge [bulk RNA-seq]

| PRJNA511441 | ENA