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Probiotic consortia improve anti-viral immunity to SARS-CoV-2 in Ferrets [RT-PCR]

ABSTRACT: Probiotic consortia improve anti-viral immunity to SARS-CoV-2 in Ferrets [RT-PCR]

PROVIDER: PRJNA748048 | ENA |

REPOSITORIES: ENA

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Probiotic consortia improve anti-viral immunity to SARS-CoV-2 in Ferrets [RT-PCR]

Project description:Probiotics have been suggested as one solution to counter detrimental health effects by SARS-CoV-2, however, data so far is scarce. We tested the effect of two probiotic consortia, OL-1 and OL-2, against SARS-CoV2 in ferrets and assessed their effect on cytokine production and transcriptome in a human monocyte- derived macrophage (Mf) and dendritic cell (DC) model. The results showed that the consortia significantly reduced the viral load, modulated immune response, and regulated viral receptor expression in ferrets compared to placebo. In human Mf and DC model, OL-1 and OL-2 induced cytokine production and genes and related to SARS-CoV-2 anti-viral immunity. The study results indicate that probiotic stimulation of the ferret immune system leads to improved anti-viral immunity against SARS-COV-2 and that critical genes and cytokines for anti-SARS-CoV-2 immunity are stimulated in human immune cells in vitro. The effect of the consortia against SARS-CoV-2 warrants further investigations in human clinical trials.

2022-04-01 | GSE180390 | GEO

Probiotic consortia improve anti-viral immunity to SARS-CoV-2 in Ferrets [RNA-seq]

2022-04-01 | GSE180389 | GEO

Probiotic consortia improve anti-viral immunity to SARS-CoV-2 in Ferrets

Project description:Probiotic consortia improve anti-viral immunity to SARS-CoV-2 in Ferrets

| PRJNA748042 | ENA

Probiotic consortia improve anti-viral immunity to SARS-CoV-2 in Ferrets [RNA-seq]

Project description:Probiotic consortia improve anti-viral immunity to SARS-CoV-2 in Ferrets [RNA-seq]

| PRJNA748049 | ENA

Probiotic consortia improve anti-viral immunity to SARS-CoV-2 in Ferrets

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-04-01 | GSE180391 | GEO

IF002 - Custom designed Agilent arrays result on the Cystic Fibrosis model in ferrets.

Project description:The goal of this study is to use newly designed ferret Agilent arrays to compare transcriptome profiles between wild type, CF3959(-/-) and CF3959(+/-) ferrets. Lung and trachea tissues from newborn and 15 day-old ferrets were RNA-extracted and subsequently analyzed by microarray. Using the newly designed ferret Agilent arrays, we compared the transcriptome profiles between wild type, CF3959(-/-) and CF3959(+/-) ferrets. Samples sets: RNA from a combination of trachea and lung tissue from 4 newborn wild type ferrets and 4 newborn CF3959(-/-) ferrets. In addition, lung tissue from two 15 day-old wild type, three 15 day-old CF3959(+/-) and three 15 day-old CF3959(-/-) ferrets was RNA-extracted and subsequently analyzed by microarray.

2014-07-18 | E-GEOD-49061 | biostudies-arrayexpress

Age-dependent pathogenic characteristics of SARS-CoV-2 infection in ferrets

Project description:While the seroprevalence of SARS-CoV-2 in healthy people does not differ significantly among age groups, those aged 65 years or older exhibit strikingly higher COVID-19 mortality compared to younger individuals. To further understand differing COVID-19 manifestations in patients of different ages, three age groups of ferrets are infected with SARS-CoV-2. Although SARS-CoV-2 is isolated from all ferrets regardless of age, aged ferrets (≥3 years old) shows higher viral loads, longer nasal virus shedding, and more severe lung inflammatory cell infiltration and clinical symptoms compared to juvenile (≤6 months) and young adult (1-2 years) groups. Furthermore, direct contact ferrets co-housed with the virus-infected aged group shed more virus than direct-contact ferrets co-housed with virus-infected juvenile or young adult ferrets. Transcriptome analysis of aged ferret lungs reveals strong enrichment of gene sets related to type I interferon, activated T cells, and M1 macrophage responses, mimicking the gene expression profile of severe COVID-19 patients. Thus, SARS-CoV-2-infected aged ferrets highly recapitulate COVID-19 patients with severe symptoms and are useful for understanding age-associated infection, transmission, and pathogenesis of SARS-CoV-2.

2021-12-31 | GSE189619 | GEO

RT² Profiler™ PCR Array Human Aging

Project description:RT² Profiler™ PCR Array Human Aging

| PRJNA594942 | ENA

Qiagen RT-PCR array Dimethylamin validation experiment

Project description:Qiagen RT-PCR array Dimethylamin validation experiment

| PRJNA1005634 | ENA

RT² Profiler™ PCR Array Human Senesence

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| PRJNA594938 | ENA