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Single-cell RNA-seq of control and Sendai virus-infected mouse lungs [1wk/7wk timepoint]

ABSTRACT: Single-cell RNA-seq of control and Sendai virus-infected mouse lungs [1wk/7wk timepoint]

PROVIDER: PRJNA750095 | ENA |

REPOSITORIES: ENA

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	SRR15265466.fastq.gz	Fastqsanger.gz

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Single-cell RNA-seq of control and Sendai virus-infected mouse lungs [1wk/7wk timepoint]

Project description:The Sendai virus infection model induces global changes involving multiple lung cell types. At 1 week post-infection, there is acute damage to the lung. At 2 weeks post-infection, when the virus had been largely cleared and the lung is undergoing repair, proliferation of endothelial cells and alveolar type 2 (AT2) cells is observed, as well as aberrant appearance Trp63/Sox2-expressing basal-like cells reminiscent of pods or lineage-negative epithelial progenitors observed upon severe H1N1 virus infection. At 7 weeks post-infection, the lung has been largely repaired, though the Trp63/Sox2-expressing basal-like cells remain.

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