Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: Research on facial skin physiological status and microbial community diversity in Chinese women with melasma

PROVIDER: PRJNA750660 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR15312200_1.fastq.gz	Fastqsanger.gz
	SRR15312200_2.fastq.gz	Fastqsanger.gz
	SRR15312300_1.fastq.gz	Fastqsanger.gz
	SRR15312300_2.fastq.gz	Fastqsanger.gz
	SRR15312201_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 358

Similar Datasets

Project description:Microbial community diversity of sensitive facial skin in Chinese women

| PRJNA753962 | ENA

Project description:Variation of facial skin physiological status and microbiome in Chinese women with different degrees of aging

| PRJNA750340 | ENA

Project description:Research on alteration of skin physiological status and skin microbiota in Chinese women with menstrual cycle disorder

| PRJNA755347 | ENA

Project description:Alteration of skin microbiome and skin physiological status in Chinese women with regularly late bedtime.

| PRJNA755153 | ENA

Transcriptional profiling shows altered expression of wnt pathway- and lipid metabolism-related genes as well as melanogenesis-related genes in melasma.

Project description:Melasma is a commonly acquired hyperpigmentary disorder of the face, but its pathogenesis is poorly understood and its treatment remains challenging. We conducted a comparative histological study on lesional and perilesional normal skin to clarify the histological nature of melasma. Significantly, higher amounts of melanin and of melanogenesis-associated proteins were observed in the epidermis of lesional skin, and the mRNA level of tyrosinase-related protein 1 was higher in lesional skin, indicating regulation at the mRNA level. However, melanocyte numbers were comparable between lesional and perilesional skin. A transcriptomic study was undertaken to identify genes involved in the pathology of melasma. A total of 279 genes were found to be differentially expressed in lesional and perilesional skin. As was expected, the mRNA levels of a number of known melanogenesis-associated genes, such as tyrosinase, were found to be elevated in lesional skin. Bioinformatics analysis revealed that the most lipid metabolism-associated genes were downregulated in lesional skin, and this finding was supported by an impaired barrier function in melasma. Interestingly, a subset of Wnt signaling modulators, including Wnt inhibitory factor 1, secreted frizzled-related protein 2, and Wnt5a, were also found to be upregulated in lesional skin. Immunohistochemistry confirmed the higher expression of these factors in melasma lesions.

2015-08-19 | GSE72140 | GEO

Project description:Human Facial Skin Mycobiomes in Korea Women

| PRJNA627798 | ENA

Project description:Human Facial Skin Microbiomes in Korea Women

| PRJNA627788 | ENA

Project description:Melasma Skin Microbiome

| PRJNA1138279 | ENA

Correlation analysis between gut microbiota characteristics and melasma

Project description:To compare the similarities and differences in species diversity of the gut microbiota between the patients with melasma and healthy subjects. The feces were collected for 16S rRNA sequencing analysis of the gut microbiota.

2022-10-25 | GSE214430 | GEO

Project description:16S rRNA Gene Sequencing Analysis of Facial Skin Microecology in Melasma Patients After QCWC Treatment

| PRJNA1225120 | ENA