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Detection of duplication mutations in coding regions in normal lung and lung tumor in wild-type (WT) and FEN1 A159V mutant mice

ABSTRACT: Detection of duplication mutations in coding regions in normal lung and lung tumor in wild-type (WT) and FEN1 A159V mutant mice

PROVIDER: PRJNA750802 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR15301095_1.fastq.gz	Fastqsanger.gz
	SRR15301095_2.fastq.gz	Fastqsanger.gz
	SRR15301096_1.fastq.gz	Fastqsanger.gz
	SRR15301096_2.fastq.gz	Fastqsanger.gz
	SRR15301097_1.fastq.gz	Fastqsanger.gz

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Detection of duplication mutations in coding regions in normal lung and lung tumor in wild-type (WT) and FEN1 A159V mutant mice

Project description:Faithful and efficient Okazaki fragment maturation is the key to maintain the genome integrity. In addition, this process is coupled with deposition of histone proteins. Therefore, functional deficiency in Okazaki fragment maturation may cause duplication mutations. We conduct WES of normal lung and lung tumor from WT and A159V/WT mice to define the duplication mutations caused by defective Okazaki fragment maturation.

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