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H3K27ac ChIP-seq of MCF10A progression series

ABSTRACT: H3K27ac ChIP-seq of MCF10A progression series

PROVIDER: PRJNA752355 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR15354200.fastq.gz	Fastqsanger.gz
	SRR15354201.fastq.gz	Fastqsanger.gz
	SRR15354202.fastq.gz	Fastqsanger.gz
	SRR15354203.fastq.gz	Fastqsanger.gz
	SRR15354204.fastq.gz	Fastqsanger.gz

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H3K27ac ChIP-seq of MCF10A progression series

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Project description:Cancer arises from complex epigenetic mechanisms that drive tumorigenesis. Gene regulatory elements play a pivotal role in reprogramming gene expression patterns, facilitating tumor initiation, progression, and metastasis. However, a comprehensive characterization of epigenetic alterations across cancer development remains incomplete, particularly for the spectrum of post-translational histone modifications in the evolution of breast tumors. In this study, we explored the dynamic landscape of epigenetic changes using a breast cancer progression model based on the MCF10A cell line. We integrated ChIP-seq and transcriptomic profiling to investigate the epigenetic heterogeneity across four MCF10A-derived cancer cell lines: normal (MCF10A), HRAS G12V transformed, ductal carcinoma in situ (DCIS), and metastatic (CA1a). Our analysis revealed significant changes in chromatin patterns at regulatory elements, including stage-specific variability in H3K27me3 and H3K9me3-marked heterochromatin domains. These profiles underly the epigenomic changes in each of these cell states to provide insights into human breast cancer progression.

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Affymetrix SNP array analysis of the breast cell lines MCF10A, MCF10AT, MCF10CA1h and MCF10CA1a

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