Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Single-cell sequencing unveils the heterogeneity of nonimmune cells in chronic apical periodontitis

ABSTRACT: Single-cell sequencing unveils the heterogeneity of nonimmune cells in chronic apical periodontitis

PROVIDER: PRJNA753049 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR15373534_1.fastq.gz	Fastqsanger.gz
	SRR15373534_2.fastq.gz	Fastqsanger.gz
	SRR15373535_1.fastq.gz	Fastqsanger.gz
	SRR15373535_2.fastq.gz	Fastqsanger.gz
	SRR15373536_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 24

Similar Datasets

Single-cell sequencing unveils the heterogeneity of nonimmune cells in chronic apical periodontitis

Project description:Chronic apical periodontitis (CAP) is a unique dynamic interaction between microbial invasions and host defense mechanisms, resulting in bone absorption, infiltration of immune cells and sporadic periapical granuloma. In this study, we constituted a single-cell atlas for 26,737 high-quality cells from hyperplastic periapical tissue using single-cell RNA sequencing. Identifying cell types and signatures at the single-cell level might generate novel insights into the clinical pathogenesis of CAP. A histological analysis to verify the gene signatures of nonimmune cells was combined with immunohistochemistry staining. We then discovered the diversity and heterogeneity of nonimmune cells in regional CAP lesions. The temporal profiling of genomic alterations from common CAP to typical periapical granuloma provided predictions for key transcription factors and biological processes. Our study also inferred that the marked shift of inflammatory cytokines, chemokines, proteases and growth factors enables the initiation of polymorphic cell differentiation, lymphangiogenesis and angiogenesis during CAP.

2021-08-31 | GSE181688 | GEO

Apical periodontitis

Project description:Apical periodontitis

| PRJEB11764 | ENA

Genomic landscape of apical periodontitis

Project description:Genomic landscape of apical periodontitis

| PRJNA952785 | ENA

Genomic landscape of apical periodontitis

Project description:Genomic landscape of apical periodontitis

| PRJNA952784 | ENA

RNA-seq analysis of RNA extracted from control alveolar bone samples and alveolar bone under apical periodontitis

Project description:To investigate the underlying mechanisms in the the states of apical periodontitis, we extracted RNA from control alveolar bone and alveolar bone under apical periodontitis.

2023-02-11 | GSE221990 | GEO

Single-Cell Sequencing Unveils the Heterogeneity of Nonimmune Cells in Chronic Apical Periodontitis.

Project description:Chronic apical periodontitis (CAP) is a unique dynamic interaction between microbial invasions and host defense mechanisms, resulting in infiltration of immune cells, bone absorption, and periapical granuloma formation. To help to understand periapical tissue pathophysiology, we constituted a single-cell atlas for 26,737 high-quality cells from inflammatory periapical tissue and uncovered the complex cellular landscape. The eight types of cells, including nonimmune cells and immune cells, were identified in the periapical tissue of CAP. Considering the key roles of nonimmune cells in CAP, we emphasized osteo-like cells, basal/stromal cells, endothelial cells, and epithelial cells, and discovered their diversity and heterogeneity. The temporal profiling of genomic alterations from common CAP to typical periapical granuloma provided predictions for transcription factors and biological processes. Our study presented potential clues that the shift of inflammatory cytokines, chemokines, proteases, and growth factors initiated polymorphic cell differentiation, lymphangiogenesis, and angiogenesis during CAP.

| S-EPMC8883837 | biostudies-literature

Transcriptomic Regulation of Apical Periodontitis by Nociceptors

Project description:Transcriptomic Regulation of Apical Periodontitis by Nociceptors

| PRJNA844075 | ENA

Single-cell gene expression of control mandibular bone marrow cells and mandibular bone marrow cells under apical periodontitis

Project description:Single-cell gene expression of mandibular bone marrow cells and mandibular bone marrow cells under the stimulation of apical periodontitis were determined by scRNAseq.

2023-02-11 | GSE212975 | GEO

Sex-specific nociceptor modulation of apical periodontitis transcriptome

Project description:Sex-specific nociceptor modulation of apical periodontitis transcriptome

| PRJNA1071131 | ENA

Differential protein expression in the alveolar bone tissue of rats with apical periodontitis

Project description:The iTRAQ method was used to analyze differences in protein expression in alveolar bone tissue during the progression of apical periodontitis in rats.

2025-01-16 | PXD059854 |

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data