Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: Microbial diversity in the mouse colon

PROVIDER: PRJNA753214 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR15403671_1.fastq.gz	Fastqsanger.gz
	SRR15403671_2.fastq.gz	Fastqsanger.gz
	SRR15403672_1.fastq.gz	Fastqsanger.gz
	SRR15403672_2.fastq.gz	Fastqsanger.gz
	SRR15403673_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 20

Similar Datasets

VDJ: Single-cell RNA sequencing of human steady-state immune cells from the lamina propria of colon and matching mesenteric lymph nodes

Project description:The human colon contains an extensively diverse microbial ecosystem and one of the most numerous communities of immune cells. Studies have highlighted dynamic crosstalk between immune cells and commensals. While studies have demonstrated increasing diversity of microbiota from stomach to stool, whether and how immune cell heterogeneity and microbiota diversity change across the colon is undefined. Furthermore, whether these changes are co-depended in the healthy colon is unknown. Here, tissue samples are collected from caecum, transverse colon, sigmoid colon and mLN of cadaveric donors by the Cambridge Biorepository of Translational Medicine (CBTM). We use single cell RNA sequencing (10X genomics) to assess the dynamics of immune cell populations across the colon and in matching lymph nodes. Associated microbiome 16S sequencing data is available.

2020-01-01 | E-MTAB-8476 | biostudies-arrayexpress

Single-cell RNA sequencing of human steady-state immune cells from the lamina propria of colon and matching mesenteric lymph nodes

2020-01-01 | E-MTAB-8007 | biostudies-arrayexpress

SS2_1: Single-cell RNA sequencing of human steady-state immune cells from the lamina propria of colon and matching mesenteric lymph nodes

2020-01-01 | E-MTAB-8484 | biostudies-arrayexpress

SS2_2: Single-cell RNA sequencing of human steady-state immune cells from the lamina propria of colon and matching mesenteric lymph nodes

2020-01-01 | E-MTAB-8486 | biostudies-arrayexpress

GEX: Single-cell RNA sequencing of human steady-state immune cells from the lamina propria of colon and matching mesenteric lymph nodes

2020-01-01 | E-MTAB-8474 | biostudies-arrayexpress

Project description:Sequencing the microbial diversity of mouse colon contents

| PRJNA1291732 | ENA

Reuterin in the healthy gut microbiome suppresses colorectal cancer growth through altering redox balance

Project description:Microbial dysbiosis is a colorectal cancer (CRC) hallmark and contributes to inflammation, tumor growth, and therapy response. Gut microbes signal via metabolites, but how the metabolites impact CRC is largely unknown. We interrogated fecal metabolites associated with mouse models of colon tumorigenesis with varying mutational load. We found that microbial metabolites from healthy mice or humans were growth-repressive, and this response was attenuated in mice and patients with CRC. Microbial profiling revealed that Lactobacillus reuteri and its metabolite, reuterin were downregulated in mouse and human CRC. Reuterin altered redox balance, and reduced survival, and proliferation in colon cancer cells. Reuterin induced selective protein oxidation, and inhibited ribosomal biogenesis and protein translation. Exogenous Lactobacillus reuteri restricted mouse colon tumor growth, increased tumor reactive oxygen species, and decreased protein translation in vivo. Our findings indicate that a healthy microbiome and specifically, Lactobacillus reuteri, is protective against CRC through microbial metabolite exchange.

2021-12-12 | GSE186880 | GEO

Project description:microbial diversity on mice colon

| PRJNA665786 | ENA

Project description:colon contents microbial community diversity

| PRJNA809888 | ENA

Project description:colon contents microbial community diversity

| PRJNA830328 | ENA