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Gene expression data from a Brazilian cohort of pediatric adrenocortical tumors

ABSTRACT: Gene expression data from a Brazilian cohort of pediatric adrenocortical tumors

PROVIDER: PRJNA754189 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR15431843_1.fastq.gz	Fastqsanger.gz
	SRR15431843_2.fastq.gz	Fastqsanger.gz
	SRR15431844_1.fastq.gz	Fastqsanger.gz
	SRR15431844_2.fastq.gz	Fastqsanger.gz
	SRR15431845_1.fastq.gz	Fastqsanger.gz

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Gene expression data from a Brazilian cohort of pediatric adrenocortical tumors

Project description:Adrenocortical tumors in children are rare, but 10-15 times more incident in Southern Brazil than in the rest of the world. However, reliable biomarkers capable of establishing a well-defined prognostic correlation or predicting relapse risk of the disease are still challenging. Herein, we aimed to compare the expression profiles of pediatric adrenocortical tumors of patients with favorable and unfavorable clinical outcomes.

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Project description:SNP array data from 13 Brazilian childhood adrenocortical tumors (ACTs) were analyzed to detect recurrent copy number changes and highlight potential candidate driver genes.

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Project description:Abnormal DNA methylation contributes to tumor progression and is emerging as a prognostic marker in several types of cancers. To investigate whether DNA methylation is associated with Pediatric Adrenocortical Tumor (pACT) presentation and patient prognosis, we analyzed the methylation profile of 57 tumors (Illumina Infinium HumanMethylation850 BeadChip) and patients’ clinicopathological features and outcome.

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Project description:SNP array data from 13 Brazilian childhood adrenocortical tumors (ACTs) were analyzed to detect recurrent copy number changes and highlight potential candidate driver genes. 13 childhood ACT were analyzed with Illumina HumanCNV370-Duo v1.0 chips. Paired normal blood samples from 6 patients were analyzed with Illumina HumanCNV370-Quad v3.0 chips.

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Gene exrpression profiling of childhood adrenocortical tumors

Project description:Pediatric adrenocortical tumors (ACT) are rare and often fatal malignancies; little is known regarding their etiology and biology. To provide additional insight into the nature of ACT, we determined the gene expression profiles of 24 pediatric tumors (five adenomas, 18 carcinomas, and one undetermined) and seven normal adrenal glands. Distinct patterns of gene expression, validated by quantitative real-time PCR and Western blot analysis, were identified that distinguish normal adrenal cortex from tumor. Differences in gene expression were also identified between adrenocortical adenomas and carcinomas. In addition, pediatric adrenocortical carcinomas were found to share similar patterns of gene expression when compared with those published for adult ACT. This study represents the first microarray analysis of childhood ACT. Our findings lay the groundwork for establishing gene expression profiles that may aid in the diagnosis and prognosis of pediatric ACT, and in the identification of signaling pathways that contribute to this disease. We used microarrays to explore the expression profiles differentially expressed in childhood adrenocortical tumors and in normal adrenal gland tissues. Pediatric adrenocortical adenoma and carcinoma patients were enrolled on the International Pediatric Adrenocortical Tumor Registry (IPACTR) and Bank protocol. Tumor specimens were harvested during surgery and snap frozen in liquid nitrogen to preserve tissue integrity. Data have been compiled for eight males and 15 females between 0 and 16 years of age. Table 1 (West et al, Cancer Research 67:601-608, 2007) summarizes the primary clinical information for each subject (excluding sample Unk1 with ACT of undetermined histology), including stage of the disease, tumor class, sex, age, relapse-free survival, and overall survival.

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