Project description:Analysis of ex vivo isolated lymphatic endothelial cells from the dermis of patients to define type 2 diabetes-induced changes. Results preveal aberrant dermal lymphangiogenesis and provide insight into its role in the pathogenesis of persistent skin inflammation in type 2 diabetes. The ex vivo dLEC transcriptome reveals a dramatic influence of the T2D environment on multiple molecular and cellular processes, mirroring the phenotypic changes seen in T2D affected skin. The positively and negatively correlated dLEC transcripts directly cohere to prolonged inflammatory periods and reduced infectious resistance of patients´ skin. Further, lymphatic vessels might be involved in tissue remodeling processes during T2D induced skin alterations associated with impaired wound healing and altered dermal architecture. Hence, dermal lymphatic vessels might be directly associated with T2D disease promotion.
Project description:African-Americans with prostate cancer tend to have a more aggressive form of the disease, as compared to their Caucasian counterparts. Nevertheless, African-Americans tend to be underrepresented in most molecular profiling studies of prostate cancer. To investigate DNA copy number alterations (CNAs) in prostate cancer from a cohort of African-Americans, we profiled 20 tumors (each with paired normal) for 500,000 SNPs. Keywords: tumor-normal comparison
