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Human retinal organoids release extracellular vesicles that regulate gene expression in target human retinal progenitors

ABSTRACT: Human retinal organoids release extracellular vesicles that regulate gene expression in target human retinal progenitors

PROVIDER: PRJNA756561 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR15539400.fastq.gz	Fastqsanger.gz
	SRR15539401.fastq.gz	Fastqsanger.gz
	SRR15539402.fastq.gz	Fastqsanger.gz
	SRR15539403.fastq.gz	Fastqsanger.gz
	SRR15539404.fastq.gz	Fastqsanger.gz

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Human retinal organoids release extracellular vesicles that regulate gene expression in target human retinal progenitors

Project description:Developing human retinal organoids and their EVs contain unique populations of small noncoding RNAs, including miRNA, piRNA and tRNA. The EV genetic cargo has functions correlated to retinal differentiation and development. Retinal organoid EVs educate multipotent retinal progenitor cell differentiation toward photoreceptor and ganglion cell fates.

2021-08-27 | GSE182520 | GEO

Tracing retinal progenitors cells and photoreceptors from mouse retinal organoids

Project description:Retinal organoids have become valuable 3D model for translational and developmental research. The knowledge of the limitations of the system ensures its sensible use. All retinal cell types originate from the differentiation of retinal progenitor cells. The properties of retinal progenitors in 3D culture systems are not well studied. In our project, we created a mouse stem cell line with a Rax-mCherry reporter construct that allows retinal progenitors' isolation, tracing, and in vitro imaging during retinogenesis. For proteomic analysis, we used mCherry-positive cells from dissociated embryoid bodies with formed eye field structures on the fourth day after stem cell aggregation. Information about protein content helped to characterize Rax-expressing cells at this stage and their suitability for further applications.

2025-02-14 | PXD039309 | Pride

Oncogene regulated release of extracellular vesicles

Project description:Oncogene regulated release of extracellular vesicles

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miRNA profile in extracellular vesicles from human muscle progenitors

Project description:miRNA profile in extracellular vesicles from human muscle progenitors

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miRNA profile in extracellular vesicles from human muscle progenitors

Project description:We investigated the enriched miRNAs in extracellular vesicles (EV) from human myoblasts and givinostat induced muscle progenitor cells which are derived from human induced pluripotent stem cells

2021-01-30 | GSE155094 | GEO

Apoptotic endothelial cells release small extracellular vesicles loaded with immunostimulatory viral-like RNAs

Project description:Purpose: Compare the RNA content of apoptotic human umbilical vein endothelial cells (HUVECs)-released vesicles: 1) Apoptotics bodies and 2) Apoptotic Exo-like vesicles, which are immunogenic and promote autoimmunity. Results: The transcriptome of ApoExos was unique with regards to its genomic origin, nucleotide composition and secondary structure. We show that ApoExos essentially contain non-ribosomal non-coding RNAs, among which 89% are derived from viral-like endogenous retroelements (EREs). ApoExos are also enriched in U-rich linear nucleotide sequences and Alus repeats. Conclusion: Our work demonstrates that apoptotic endothelial cells release EVs loaded with RNAs recognized by RLRs and endosomal TLRs (TLR3, TLR7 and TLR8), and are therefore tailor-made for initiation of innate immune responses and autoimmunity.

2019-05-10 | GSE119108 | GEO

miRNA expression data from CD73-positive Rods, MÃ¼ler glia and E 17.5 Retinal Progenitors

Project description:During retinal development, progenitor cells give rise to six different types of neurons, and one glial cell. This process requires the expression of genes that confer specific functions and identity to each cell. Previous works have reported the miRNAs expression profile in retina, but is still necessary to further define individual retinal cell populations profiles. We isolated postmitotic mice CD73-positive Rods, MÃ¼ller glial cells and Retinal Progenitors Cells (E17.5); we then analyzed their miRNA profile expression by microarrays. Using wild type mice we FACS-isolated postmitotic CD73-positive Rods (posnatal day 5). We isolated primary MÃ¼ller glia cultures from postnatal day 8 mice and retinal progenitors cells from E17.5 mouse embryos; we then sent the samples to the gene expression unit at Instituto de Medicina Genomica (INMEGEN), to analyze their miRNA profile expression by microarrays.

2016-02-09 | E-GEOD-62109 | biostudies-arrayexpress

Transcriptional profiling of retinal progenitors, exposed to endothelial cells or EGF

Project description:Retinal histogenesis occurs over an extended period, which necessitates retinal progenitors to self-renew to sustain the temporal generation of diverse cell types. Embryonic day 18 retinal cells showed self-renewal properties such as clonal propagation without compromising multipotentiality when grown in the presence of endothelial cell conditioned medium and not EGF alone.

2013-12-14 | GSE53305 | GEO

Bankable human iPSC-derived Retinal Progenitors as a New Source of Multipotent Cells

Project description:Bankable human iPSC-derived Retinal Progenitors as a New Source of Multipotent Cells

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Extracellular vesicles of human diabetic retinopathy retinal tissue and urine of diabetic retinopathy patients analyzed using mass spectrometry

Project description:Diabetic Retinopathy (DR) is a potentially blinding retinal disorder which develops through the pathogenesis of diabetes. Extracellular Vesicles (EVs) provide a novel biomarker for pre-symptomatic disease diagnosis and prognosis. Proteomic analysis was performed on explanted DR retinal tissue, DR retinal EVs and DR urinary EVs. DR samples were compared to normal retinal tissue, retinal EVs and urinary EVs, respectively

2022-12-31 | PXD034626 | Pride

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