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Bat metagenome

ABSTRACT: Discovery and characterization of a novel bat coronavirus sheds light on the origin of emerging infectious diseases

PROVIDER: PRJNA756962 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR15661518.fastq.gz	Fastqsanger.gz
	SRR15661518_1.fastq.gz	Fastqsanger.gz
	SRR15661518_2.fastq.gz	Fastqsanger.gz

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Project description:SARS-CoV-2 has caused the largest known coronavirus pandemic and is believed to have emerged from insectivorous bats. Little is known about the evolution of these viruses in their reservoir bat species. In this study, we investigated SARS-CoV-2-host interaction using human and bat cells. Bat cells mount a robust and early antiviral response but elicit a dampened pro-inflammatory response upon SARS-CoV-2 infection compared to human cells. Furthermore, an inactivating R685P mutation within the furin cleavage site (FCS) of the SARS-CoV-2 spike protein was naturally selected for in infected bat cells. Taken together, our data demonstrate that insectivorous bat cells have evolved a differential antiviral immune response against SARS-CoV-2 infection, likely to mitigate immunopathology that is observed in humans. Our study sheds light on the evolution of sarbecoviruses in bats and extends molecular evidence to data from field studies that have demonstrated that SARS-CoV-2-related viruses in wild-caught bats lack an intact FCS.

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