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Epigenetic inheritance mediates phenotypic evolution in natural populations

ABSTRACT: Epigenetic inheritance mediates phenotypic evolution in natural populations

PROVIDER: PRJNA762005 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR15830356.fastq.gz	Fastqsanger.gz
	SRR15830357.fastq.gz	Fastqsanger.gz
	SRR15830358.fastq.gz	Fastqsanger.gz
	SRR15830359.fastq.gz	Fastqsanger.gz
	SRR15830360.fastq.gz	Fastqsanger.gz

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Epigenetic inheritance mediates phenotypic evolution in natural populations

Project description:Genetic variation is regarded as a prerequisite for evolution. Theoretical models suggest epigenetic information inherited independently of DNA sequence can also enable evolution. However, whether epigenetic inheritance mediates phenotypic evolution in natural populations is unknown. Here we show that natural epigenetic DNA methylation variation in gene bodies regulates genes expression, and thereby influences the natural variation of complex traits in Arabidopsis thaliana. Notably, the effects of methylation variation on phenotypic diversity and gene expression variance are comparable with those of DNA sequence polymorphism. We also identify methylation epialleles in numerous genes associated with environmental conditions in native habitats, suggesting that intragenic methylation facilitates adaptation to fluctuating environments. Our results demonstrate that methylation variation fundamentally shapes phenotypic diversity in natural populations and provides an epigenetic basis for adaptive Darwinian evolution independent of genetic polymorphism.

2022-06-30 | GSE183785 | GEO

PRC2 mediates paternal epigenetic inheritance

Project description:PRC2 mediates paternal epigenetic inheritance

| PRJNA282028 | ENA

PRC2 mediates paternal epigenetic inheritance: comparison of heterozygous mutant embryos

Project description:Determining the mechanisms that establish and regulate the transmission of non-genetic (i.e. epigenetic) information from parent to offspring is critical for understanding disease heredity. Using an innovative model to assess transmission of epigenetic effects, we provide evidence that Polycomb Repressive Complex 2 (PRC2) mediates inheritance through the male germline. This study reveals a novel role for histone modifying complexes in epigenetic inheritance, with important implications for understanding disease inheritance.

2018-02-09 | GSE68212 | GEO

PRC2 mediates paternal epigenetic inheritance: comparison of wild-type embryos

2018-02-09 | GSE68211 | GEO

RNAi mediates allele-specific epigenetic inheritance of heterochromatin

Project description:RNAi mediates allele-specific epigenetic inheritance of heterochromatin

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Transgenerational Epigenetic and Phenotypic Inheritance Across Five Generations in Sheep

Project description:Transgenerational Epigenetic and Phenotypic Inheritance Across Five Generations in Sheep

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RNAi mediates allele-specific epigenetic inheritance of heterochromatin [ChIP-seq]

Project description:RNAi mediates allele-specific epigenetic inheritance of heterochromatin [ChIP-seq]

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RNAi mediates allele-specific epigenetic inheritance of heterochromatin [ncRNA-seq]

Project description:RNAi mediates allele-specific epigenetic inheritance of heterochromatin [ncRNA-seq]

| PRJNA438370 | ENA

Polycomb protein SCML2 mediates paternal epigenetic inheritance through sperm chromatin

Project description:Polycomb protein SCML2 mediates paternal epigenetic inheritance through sperm chromatin

| PRJNA762589 | ENA

Polycomb protein SCML2 mediates paternal epigenetic inheritance through sperm chromatin

Project description:Sperm chromatin retains small amounts of histones, and the chromatin states of sperm mirror gene expression programs of the next generation. It remains largely unknown how paternal epigenetic information is transmitted through sperm chromatin. Here we developed a novel mouse model of paternal epigenetic inheritance in which deposition of Polycomb repressive complex 2 (PRC2) mediated-repressive H3K27me3 is attenuated in the paternal germline. By applying modified methods of assisted reproductive technology, we rescued infertility of mice absent of Polycomb protein SCML2, which is the regulator of germline gene expression through the establishment of H3K27me3 on bivalent promoters with other active marks H3K4me2/3. In F1 males of Scml2-knockout mice, which has wild-type genotype, gene expression is dysregulated in the male germline during spermiogenesis. These dysregulated genes are targets of SCML2-mediated H3K27me3 in mature sperm. Thus, SCML2 mediates intergenerational inheritance of paternal epigenetic information through the regulation of sperm chromatin.

2023-05-06 | GSE183994 | GEO

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