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ANALYSIS OF THE GENETIC EXPRESSION PROFILES OF SENSITIVE AND MULTIPHARMACORRESISTANT Mycobacterium tuberculosis CLONES EXPOSED TO NEW COMPOUNDS

ABSTRACT: ANALYSIS OF THE GENETIC EXPRESSION PROFILES OF SENSITIVE AND MULTIPHARMACORRESISTANT Mycobacterium tuberculosis CLONES EXPOSED TO NEW COMPOUNDS

PROVIDER: PRJNA763501 | ENA |

REPOSITORIES: ENA

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ANALYSIS OF THE GENETIC EXPRESSION PROFILES OF SENSITIVE AND MULTIPHARMACORRESISTANT Mycobacterium tuberculosis CLONES EXPOSED TO NEW COMPOUNDS

Project description:The aim of this study was to evaluate the effect of new compounds exposure on gene expression of sensitive and MDR clones of M. tuberculosis

2021-11-01 | GSE184172 | GEO

Basal mRNA expression levels of single-cell derived FaDu clones with cisplatin-sensitive / resistant phenotype

Project description:The extent of intratumoral heterogeneity, the subclonal structures and the mechanisms of treatment-induced clonal selection by cisplatin was investigated in the squamous cell carcinoma cell line model FaDu. We picked 96 single cell-derived clones from the cisplatin-sensitive parental FaDu cell line. After expansion as separate cultures, these clones were tested for their sensitivity to CDDP. By this approach, we isolated individual cell clones that were primarily resistant (clones 5 & 78) and others that showed high sensitivity to CDDP (clones 46 & 54). Basal mRNA expression levels associated with CDDP sensitivity / resistance were determined in two independent microarray analyses.

2017-12-04 | E-MTAB-6022 | biostudies-arrayexpress

HepG2 cells exposed to pesticides and related compounds

Project description:HepG2 cells were exposed for 24 hours to the IC20 (72hr MTT) dose of various pesticides and related compounds selected from the EPA Toxcast phase 1 set. This is the first part of two batches of experiments, these experiments were used as a training set and the second batch as a validation set.

2019-06-20 | E-MTAB-3508 | biostudies-arrayexpress

Expression data from glioblastoma stem cell clones (GSC)

2013-11-01 | GSE46531 | GEO

HepG2 cells exposed to pesticides and related compounds (part 2)

Project description:HepG2 cells were exposed for 24 hours to the IC20 (72hr MTT) dose of various pesticides and related compounds selected from the EPA Toxcast phase 1 set. This is the first part of two batches of experiments, these experiments were used as a validation set and the first batch as a training set.

2019-06-20 | E-MTAB-3509 | biostudies-arrayexpress

RNA-seq of human monocyte derived macrophages exposed to different atherogenic compounds

Project description:RNA-seq of human monocyte derived macrophages exposed to different atherogenic compounds

| PRJEB65093 | ENA

Mycobacterium tuberculosis clinical isolates in China: extensively drug-resistant tuberculosis vs drug sensitive one

Project description:Transcriptional profiling of mycobacterium tuberculosis clinical isolates in China comparing extensively drug-resistant tuberculosis with drug sensitive one.

2009-04-04 | GSE15540 | GEO

Transcriptional responses of Folsomia candida exposed to polar and apolar narcotizing compounds.

Project description:Narcosis or baseline toxicity is the inert toxicity of hydrophobic compounds, supposed to take place at the level of the cellular membranes. Based on the linear relationship between the toxicity (logEC50) and the hydrophobicity (logKow), class I and II narcotizing compounds are recognized, in which the latter group is assumed to exert additional toxic mechanisms by hydrogen bond donor acidity by their polar groups. Chlorinated anilines, which occur often in the environment as degradation products of certain pesticides , are considered to be narcotizing compounds. In this study the transcriptional responses of the soil arthropod Folsomia candida are investigated upon exposure to a series of anilines with increasing chlorination. A discrimination between class1 and class2 narcotizing compound is being made. Twenty-three day old Folsomia candida were exposed in LUFA 2.2 standard soil for two days to the EC50 concentrations of the following compounds: aniline, 4-chloroaniline, 3.5-dichloroaniline, 2,3,4-trichloroaniline, 2,3,5,6-tetrachloroaniline, pentachloroaniline and 1,2,3,4-tetrachlorobenzene.1,2,3,4-tetrachlrobenzene was included in the experimental design as a posiitive control of a narcotic class 1 compound. Four biological replicates were used for every treatment and a dye swap was used with the Cy3/Cy5 labels. This resulted in 32 samples which were analysed in 16 hybridisations executed in an interwoven loop design. The solvent (for spiking the soil) control was used as the reference treatment in the data analysis.

2010-02-02 | E-GEOD-19929 | biostudies-arrayexpress

Sensitive and robust gene expression changes in fish exposed to estrogen - a microarray approach

Project description:Background Vitellogenin is a well established biomarker for estrogenic exposure in fish. However, effects on gonadal differentiation at concentrations of estrogen not sufficient to give rise to a measurable vitellogenin response suggest that more sensitive biomarkers would be useful. Induction of zona pellucida genes may be more sensitive but their specificities are not as clear. The objective of this study was to find additional sensitive and robust candidate biomarkers of estrogenic exposure. Results Hepatic mRNA expression profiles were characterized in juvenile rainbow trout exposed to a measured concentration of 0.87 and 10ng ethinylestradiol/L using a salmonid cDNA microarray. The higher concentration was used to guide the subsequent identification of generally more subtle responses at the low concentration not sufficient to induce vitellogenin. A meta-analysis was performed with data from the present study and three similar microarray studies using different fish species and platforms. Within the generated list of presumably robust responses, several well-known estrogen-regulated genes were identified. Two genes, confirmed by quantitative RT-PCR (qPCR), fulfilled both the criteria of high sensitivity and robustness; the induction of the genes encoding zona pellucida protein 3 and a nucleoside diphosphate kinase (nm23). Conclusions The cross-species, cross-platform meta-analysis correctly identified several robust responses. This adds confidence to our approach used for identifying candidate biomarkers. Specifically, we propose that analyses of nm23 together with zona pellucida genes may increase the possibilities to detect an exposure to low levels of estrogenic compounds in fish.

2007-07-24 | E-MEXP-1149 | biostudies-arrayexpress

Expression data from glioblastoma stem cell clones (GSC)

Project description:Comparison of treatment sensitive GSC clones (TSGC) with treatment resistant GSC clones (TRGC). We used microarrays to identify molecular signatures of TRGC (upregulated genes). We used radiation treatment (RT) or RT plus TMZ to select treatment resistant GSC clones (TRGC)

2013-11-01 | E-GEOD-46531 | biostudies-arrayexpress

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