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Placental exosomes

ABSTRACT: Placental exosomes

PROVIDER: PRJNA763530 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR15865474.fastq.gz	Fastqsanger.gz
	SRR15865475.fastq.gz	Fastqsanger.gz
	SRR15865476.fastq.gz	Fastqsanger.gz
	SRR15865477.fastq.gz	Fastqsanger.gz
	SRR15865478.fastq.gz	Fastqsanger.gz

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Human Placental Exosomes in Gestational Diabetes Mellitus Carry a Specific Set of miRNAs Associated with Skeletal Muscle Insulin Sensitivity

Project description:The objective of this study was to investigate whether placental exosomes in gestational diabetes mellitus (GDM) carries a specific set of miRNAs associated with skeletal muscle insulin sensitivity. Exosomes were isolated from chorionic villi-conditioned media and plasma from normal and GDM pregnancies. A specific set of miRNAs was identified to be selectively enriched within exosomes when compared to their cells of origin indicating specific packaging of miRNAs into exosomes. In addition, miRNA expression varies in a consistent pattern in placenta, placental-derived exosomes, circulating exosomes and skeletal muscle in GDM.

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Environmental Pollutant Induced Cellular Injury is Reflected in Exosomes from Placental Explants

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Placental trophoblast cells-derived exosomal microRNA-1290 promotes the interaction between endometrium and embryo by targeting LHX6

Project description:Communication between the maternal uterus and the embryo is vital for a successful pregnancy. Exosomes, subtypes of extracellular vesicles comprising many bioactive factors regulate the early stages of pregnancy, specifically during embryo implantation. Nevertheless, the mechanism by which exosomal microRNAs (miRNAs) derived from placental trophoblasts regulate embryo implantation remains elusive. Herer, we isolated and identified exosomes derived from placental trophoblasts cells (HTR8/SVneo). Subsequently, we evaluated the loading miRNA in exosomes by small RNA sequencing. This study provides novel insights into the mechanism of trophoblasts cells-derived exosomes during embryo implantation.

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placental transcriptome

Project description:placental transcriptome

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