Project description:An Infinium microarray platform (GPL28271, HorvathMammalMethylChip40) was used to generate DNA methylation data from human tissue samples. n=144 EDTA blood samples and n=240 blood samples
Project description:DNA methylation is tissue specific, which has profound implications for data analysis. While both capillary and venous blood samples are whole blood, they are not identical in their clinical profiles. Here we assess the congruency of DNA methylation from 20 individuals with matched venous and capillary blood draw DNA methylation. We used DNA methylation profiles from Illumina EPIC v2 arrays assess the differences of these blood sources in quality control approches, in predicted immune cell proportions, in DNA methylation based predictors including epigenetic clocks and lifestyle predictors, and performed an examplar EWAS